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    RHA2B RING-H2 finger protein 2B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814644, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RHA2B
    Official Full Name
    RING-H2 finger protein 2B
    Primary source
    TAIR:AT2G01150
    Locus tag
    AT2G01150
    See related
    Araport:AT2G01150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F10A8.3; F10A8_3; RING-H2 finger protein 2B; RING-H2 FINGER PROTEIN RHA2B
    Summary
    Encodes a RING-H2 finger protein that is expressed in vascular tissue, root tips, embryos and pistils.
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    Genomic context

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    See RHA2B in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (100484..101566)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 4 Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene Aldolase superfamily protein Neighboring gene tRNA-Asn Neighboring gene bidirectional amino acid transporter 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene trap Dissociation insertion line, associated with a RING-H2 finger gene, shows tissue specific and developmental regulated expression of the gene in Arabidopsis. Lechner E, et al. Gene, 2002 May 15. PMID 12062802
    2. The Ubiquitin E3 Ligase RHA2b Promotes Degradation of MYB30 in Abscisic Acid Signaling. Zheng Y, et al. Plant Physiol, 2018 Sep. PMID 30030326, Free PMC Article
    3. The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic acid signaling and drought response. Li H, et al. Plant Physiol, 2011 Jun. PMID 21478367, Free PMC Article
    4. Interactions between plant RING-H2 and plant-specific NAC (NAM/ATAF1/2/CUC2) proteins: RING-H2 molecular specificity and cellular localization. Greve K, et al. Biochem J, 2003 Apr 1. PMID 12646039, Free PMC Article
    5. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the RING-type ubiquitin E3 ligase RHA2b, which positively regulates abscisic acid (ABA) signaling, interacted with and ubiquitinated transcription factor MYB30 to modulate MYB30 stability.
      Title: The Ubiquitin E3 Ligase RHA2b Promotes Degradation of MYB30 in Abscisic Acid Signaling.
    2. RHA2b and RHA2a may have redundant yet distinguishable functions in the regulation of abscissic acid responses.
      Title: The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic acid signaling and drought response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001335035.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    involved_in positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING-H2 finger protein 2B
    NP_001318169.1
    • RING-H2 finger protein 2B (RHA2B); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 finger A2A (TAIR:AT1G15100.1); Has 8536 Blast hits to 8514 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2151; Fungi - 713; Plants - 4534; Viruses - 16; Other Eukaryotes - 1122 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      100484..101566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335036.1 → NP_001324450.1  RING-H2 finger protein 2B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B063, A0A5S9WWB9, A0A654EQW0

    2. NM_126177.3 → NP_565253.2  RING-H2 finger protein 2B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B060, A0A5S9WWB9, A0A654EQW0

    3. NM_001335035.1 → NP_001318169.1  RING-H2 finger protein 2B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZU51
      UniProtKB/TrEMBL
      A0A178VYS5, A0A384KIF8, Q1H5F4
      Conserved Domains (3) summary
      COG5243
      Location:14 → 119
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:74 → 115
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:74 → 119
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZU51.2

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