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    Saposin-like aspartyl protease family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842526, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Saposin-like aspartyl protease family protein
    Primary source
    TAIR:AT1G62290
    Locus tag
    AT1G62290
    See related
    Araport:AT1G62290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19K23.21; F19K23_21
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (23009885..23013601, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SLAC1 homologue 1 Neighboring gene WRKY family transcription factor Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome, metabolome and suppressor analysis reveal an essential role for the ubiquitin-proteasome system in seedling chloroplast development. Talloji P, et al. BMC Plant Biol, 2022 Apr 8. PMID 35395773, Free PMC Article
    2. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001036142.3
    NM_001334023.1
    NM_001334024.1
    NM_001334025.1
    NM_001334026.1
    NM_104909.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to light intensity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Saposin-like aspartyl protease family protein
    NP_001031219.1
    • Saposin-like aspartyl protease family protein; FUNCTIONS IN: aspartic-type endopeptidase activity; INVOLVED IN: proteolysis, lipid metabolic process; LOCATED IN: vacuole; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, seedling growth, petal differentiation and expansion stage, LP.08 eight leaves visible; CONTAINS InterPro DOMAIN/s: Saposin-like (InterPro:IPR011001), Peptidase aspartic (InterPro:IPR021109), Peptidase aspartic, catalytic (InterPro:IPR009007), Saposin-like type B, 1 (InterPro:IPR007856), Saposin-like type B, 2 (InterPro:IPR008138), Saposin B (InterPro:IPR008139), Peptidase A1 (InterPro:IPR001461), Peptidase aspartic, active site (InterPro:IPR001969); BEST Arabidopsis thaliana protein match is: aspartic proteinase A1 (TAIR:AT1G11910.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_176419.2
    • Saposin-like aspartyl protease family protein; FUNCTIONS IN: aspartic-type endopeptidase activity; INVOLVED IN: proteolysis, lipid metabolic process; LOCATED IN: vacuole; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, seedling growth, petal differentiation and expansion stage, LP.08 eight leaves visible; CONTAINS InterPro DOMAIN/s: Saposin-like (InterPro:IPR011001), Peptidase aspartic (InterPro:IPR021109), Peptidase aspartic, catalytic (InterPro:IPR009007), Saposin-like type B, 1 (InterPro:IPR007856), Saposin-like type B, 2 (InterPro:IPR008138), Saposin B (InterPro:IPR008139), Peptidase A1 (InterPro:IPR001461), Peptidase aspartic, active site (InterPro:IPR001969); BEST Arabidopsis thaliana protein match is: aspartic proteinase A1 (TAIR:AT1G11910.1); Has 7282 Blast hits to 5100 proteins in 420 species: Archae - 0; Bacteria - 6; Metazoa - 4064; Fungi - 1685; Plants - 579; Viruses - 0; Other Eukaryotes - 948 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23009885..23013601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036142.3 → NP_001031219.1  Saposin-like aspartyl protease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04593, Q8VYL3
      UniProtKB/TrEMBL
      A0A5S9WNL7, A0A654EK95
      Conserved Domains (4) summary
      cd06098
      Location:79 → 511
      phytepsin; Phytepsin, a plant homolog of mammalian lysosomal pepsins
      PLN03146
      Location:7 → 143
      PLN03146; aspartyl protease family protein; Provisional
      pfam03489
      Location:322 → 355
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:387 → 422
      SapB_1; Saposin-like type B, region 1

    2. NM_001334024.1 → NP_001322880.1  Saposin-like aspartyl protease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVE7, A0A654EK95

    3. NM_001334023.1 → NP_001322882.1  Saposin-like aspartyl protease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVH3, A0A654EK95

    4. NM_104909.5 → NP_176419.2  Saposin-like aspartyl protease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176419.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04593, Q8VYL3
      UniProtKB/TrEMBL
      A0A5S9WNL7, A0A654EK95
      Conserved Domains (4) summary
      cd06098
      Location:79 → 511
      phytepsin; Phytepsin, a plant homolog of mammalian lysosomal pepsins
      PLN03146
      Location:7 → 143
      PLN03146; aspartyl protease family protein; Provisional
      pfam03489
      Location:322 → 355
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:387 → 422
      SapB_1; Saposin-like type B, region 1

    5. NM_001334025.1 → NP_001322879.1  Saposin-like aspartyl protease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVA7, A0A654EK95

    6. NM_001334026.1 → NP_001322881.1  Saposin-like aspartyl protease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVE7, A0A654EK95
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYL3.1

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