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    HCS2 holocarboxylase synthetase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840632, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HCS2
    Official Full Name
    holocarboxylase synthetase 2
    Primary source
    TAIR:AT1G37150
    Locus tag
    AT1G37150
    See related
    Araport:AT1G37150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28L22.1; F28L22_1; holocarboxylase synthetase 2
    Summary
    Although HCS2 is predicted to encode a biotin protein ligase / holocarboxylase synthetase (HCS), hcs2 mutants do not show a decrease in HCS activity. A dual-targeted HCS1 (At2g25710) might account for the HCS activity observed in multiple subcellular compartments in Arabidopsis.
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    Genomic context

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    See HCS2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (14174798..14178034, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene nitrate reductase 2 Neighboring gene MEI2 C-terminal RRM only like 1 Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual targeting of Arabidopsis holocarboxylase synthetase1: a small upstream open reading frame regulates translation initiation and protein targeting. Puyaubert J, et al. Plant Physiol, 2008 Feb. PMID 18156294, Free PMC Article
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001333187.1
    NM_001333188.1
    NM_001333189.1
    NM_001333190.1
    NM_001333191.1
    NM_103366.3
    NM_180625.1
    NM_180626.2
    NM_180627.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables biotin--[biotin carboxyl-carrier protein] ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    holocarboxylase synthetase 2
    NP_174903.3
    • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin protein ligase, C-terminal (InterPro:IPR003142), Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 6001 Blast hits to 6001 proteins in 2273 species: Archae - 223; Bacteria - 3976; Metazoa - 118; Fungi - 132; Plants - 62; Viruses - 0; Other Eukaryotes - 1490 (source: NCBI BLink).
    NP_850956.1
    • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 5973 Blast hits to 5971 proteins in 2277 species: Archae - 223; Bacteria - 3992; Metazoa - 119; Fungi - 132; Plants - 61; Viruses - 0; Other Eukaryotes - 1446 (source: NCBI BLink).
    NP_850957.1
    • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin protein ligase, C-terminal (InterPro:IPR003142), Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 6007 Blast hits to 6005 proteins in 2275 species: Archae - 225; Bacteria - 3982; Metazoa - 119; Fungi - 134; Plants - 60; Viruses - 0; Other Eukaryotes - 1487 (source: NCBI BLink).
    NP_850958.1
    • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 6049 Blast hits to 6045 proteins in 2294 species: Archae - 225; Bacteria - 4030; Metazoa - 120; Fungi - 134; Plants - 62; Viruses - 0; Other Eukaryotes - 1478 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      14174798..14178034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180627.2 → NP_850958.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WP99
      Conserved Domains (2) summary
      COG0340
      Location:82 → 280
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam03099
      Location:78 → 206
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    2. NM_001333188.1 → NP_001320615.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WP99, A0A1P8ANC7

    3. NM_001333187.1 → NP_001320614.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WP99, A0A1P8ANC7

    4. NM_001333189.1 → NP_001320613.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WP99

    5. NM_001333190.1 → NP_001320616.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WP99

    6. NM_001333191.1 → NP_001320617.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WP99, A0A1P8AND5

    7. NM_103366.3 → NP_174903.3  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174903.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I4W1, Q8S4V6
      Conserved Domains (3) summary
      COG0340
      Location:39 → 278
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:225 → 279
      BPL_C; Biotin protein ligase C terminal domain
      pfam03099
      Location:37 → 163
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    8. NM_180626.2 → NP_850957.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I4W2, Q8S4V5, Q8S4V7, Q9SHR6
      UniProtKB/TrEMBL
      A0A5S9WM69, A0A654EFN7
      Conserved Domains (3) summary
      COG0340
      Location:82 → 321
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam02237
      Location:268 → 322
      BPL_C; Biotin protein ligase C terminal domain
      pfam03099
      Location:78 → 206
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

    9. NM_180625.1 → NP_850956.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8S4V3, Q8S4V4
      Conserved Domains (2) summary
      COG0340
      Location:11 → 197
      BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
      pfam03099
      Location:1 → 123
      BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I4W2.1

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