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    CSN5B COP9-signalosome 5B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843463, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSN5B
    Official Full Name
    COP9-signalosome 5B
    Primary source
    TAIR:AT1G71230
    Locus tag
    AT1G71230
    See related
    Araport:AT1G71230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AJH2; COP9-signalosome 5B; CSN5; F3I17.12; F3I17_12
    Summary
    Encodes a subunit of the COP9 complex, similar to JAB1, a specific mammalian coactivator of AP-1 transcription. Involved in protein deneddylation. Double mutants with CSN5A are constitutively photomorphogenic (de-etiolated) and have abnormal auxin responses.
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    Genomic context

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    See CSN5B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (26852406..26854419)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene EMS-MUTAGENIZED BRI1 SUPPRESSOR 1 Neighboring gene uncharacterized protein Neighboring gene chromosome-partitioning protein, putative (DUF639)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C2H2 zinc-finger protein SlZF3 regulates AsA synthesis and salt tolerance by interacting with CSN5B. Li Y, et al. Plant Biotechnol J, 2018 Jun. PMID 29193661, Free PMC Article
    2. D27E mutation of VTC1 impairs the interaction with CSN5B and enhances ascorbic acid biosynthesis and seedling growth in Arabidopsis. Li S, et al. Plant Mol Biol, 2016 Nov. PMID 27561782
    3. Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis. Wang J, et al. Plant Cell, 2013 Feb. PMID 23424245, Free PMC Article
    4. Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome. Dohmann EM, et al. Plant Physiol, 2008 Jul. PMID 18467458, Free PMC Article
    5. Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis. Dohmann EM, et al. Plant Cell, 2005 Jul. PMID 15923347, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. interacts with salt-inducible Solanum lycopersicum ZF3 (GenBank Accession No. DY523809 and SGN Accession No. Solyc06g075780)
      Title: The C2H2 zinc-finger protein SlZF3 regulates AsA synthesis and salt tolerance by interacting with CSN5B.
    2. Data reveal that the 27th amino acid of VTC1 confers a key regulation in the interaction with CSN5B and AsA biosynthesis, as well as in Arabidopsis seedling growth.
      Title: D27E mutation of VTC1 impairs the interaction with CSN5B and enhances ascorbic acid biosynthesis and seedling growth in Arabidopsis.
    3. a regulatory role of CSN5B in light-dark regulation of ascorbic acid synthesis
      Title: Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis.
    4. Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
      Title: The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    5. not essential for auxin responses
      Title: Auxin responses in mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome.
    6. unequal role that CSN(CSN5A) and CSN(CSN5B) play in controlling the cellular derubylation of cullins
      Title: The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.
    7. Results indicate that although CSN6A and CSN6B retain mostly redundant functions, CSN5A and CSN5B play unequal roles in the regulation of plant development.
      Title: Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334491.1
    NM_105792.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of photomorphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    COP9-signalosome 5B
    NP_177279.1
    • COP9-signalosome 5B (CSN5B); CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555); BEST Arabidopsis thaliana protein match is: COP9 signalosome 5A (TAIR:AT1G22920.1); Has 1278 Blast hits to 1275 proteins in 253 species: Archae - 0; Bacteria - 6; Metazoa - 459; Fungi - 394; Plants - 243; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26852406..26854419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105792.2 → NP_177279.1  COP9-signalosome 5B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82523, Q9FVU9
      UniProtKB/TrEMBL
      A0A178WIT6, A0A654EN23
      Conserved Domains (1) summary
      cd08069
      Location:48 → 321
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    2. NM_001334491.1 → NP_001321294.1  COP9-signalosome 5B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQF0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FVU9.1

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