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    GCS1 glucosidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843070, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCS1
    Official Full Name
    glucosidase 1
    Primary source
    TAIR:AT1G67490
    Locus tag
    AT1G67490
    See related
    Araport:AT1G67490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glucosidase 1; KNF; KNOPF; T1F15.4; T1F15_4
    Summary
    Encodes an alpha-glucosidase I enzyme that catalyzes the first step in N-linked glycan processing. Localized to the endoplasmic reticulum (ER).
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    Genomic context

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    See GCS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Sequence:
    Chromosome: 1; NC_003070.9 (25280410..25286749, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene ncRNA Neighboring gene microRNA ath-MIR839 precursor Neighboring gene recovery protein 3 Neighboring gene Leucine-rich repeat protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER. Boulaflous A, et al. BMC Plant Biol, 2009 Dec 8. PMID 19995436, Free PMC Article
    2. A novel mutation in KNOPF uncovers the role of alpha-glucosidase I during post-embryonic development in Arabidopsis thaliana. Furumizu C, et al. FEBS Lett, 2008 Jun 25. PMID 18503769
    3. Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway. Saint-Jore-Dupas C, et al. Plant Cell, 2006 Nov. PMID 17138701, Free PMC Article
    4. Alpha-glucosidase I is required for cellulose biosynthesis and morphogenesis in Arabidopsis. Gillmor CS, et al. J Cell Biol, 2002 Mar 18. PMID 11901167, Free PMC Article
    5. Arabidopsis glucosidase I mutants reveal a critical role of N-glycan trimming in seed development. Boisson M, et al. EMBO J, 2001 Mar 1. PMID 11230125, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arginine residues in the cytosolic tail of AtGCSI contain ER localization information.
      Title: Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER.
    2. knf-101 mutation alters cell shape but does not affect cell arrangements, except for the patterning of specialized epidermal cells, delineating the significance of N-glycan processing during epidermal development in Arabidopsis.
      Title: A novel mutation in KNOPF uncovers the role of alpha-glucosidase I during post-embryonic development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001036170.1
    NM_105416.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,4-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucosidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plant epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within root epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glucosidase 1
    NP_001031247.1
    • glucosidase 1 (GCS1); FUNCTIONS IN: alpha-glucosidase activity; INVOLVED IN: root epidermal cell differentiation, epidermal cell differentiation; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 63 (InterPro:IPR004888), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: Six-hairpin glycosidases superfamily protein (TAIR:AT1G24320.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_176916.2
    • glucosidase 1 (GCS1); FUNCTIONS IN: alpha-glucosidase activity; INVOLVED IN: root epidermal cell differentiation, epidermal cell differentiation; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 63 (InterPro:IPR004888), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: Six-hairpin glycosidases superfamily protein (TAIR:AT1G24320.1); Has 477 Blast hits to 469 proteins in 208 species: Archae - 2; Bacteria - 128; Metazoa - 110; Fungi - 127; Plants - 43; Viruses - 0; Other Eukaryotes - 67 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25280410..25286749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105416.5 → NP_176916.2  glucosidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176916.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HTM2, F4HTM3, O64796, Q8GWC8, Q940D4, Q9C5B4, Q9CAG7
      UniProtKB/TrEMBL
      A0A5S9WSJ5
      Conserved Domains (2) summary
      pfam03200
      Location:348 → 847
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:109 → 274
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

    2. NM_001036170.1 → NP_001031247.1  glucosidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031247.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WSJ5
      Conserved Domains (2) summary
      pfam03200
      Location:264 → 763
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:109 → 126
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HTM3.1

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