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    LACS2 long-chain acyl-CoA synthetase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841367, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LACS2
    Official Full Name
    long-chain acyl-CoA synthetase 2
    Primary source
    TAIR:AT1G49430
    Locus tag
    AT1G49430
    See related
    Araport:AT1G49430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F13F21.14; F13F21_14; LATERAL ROOT DEVELOPMENT 2; long-chain acyl-CoA synthetase 2; LRD2
    Summary
    Encodes a long chain acyl-CoA synthetase that catalyzes the synthesis of omega-hydroxy fatty acyl-CoA intermediates in the pathway to cutin synthesis. Required for repression of lateral root formation.
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    Genomic context

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    See LACS2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (18290942..18295905)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein family (UPF0497) Neighboring gene translocase of the outer mitochondrial membrane 6 Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene low-molecular-weight cysteine-rich 16 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long-chain acyl-CoA synthetase 2 is involved in seed oil production in Brassica napus. Ding LN, et al. BMC Plant Biol, 2020 Jan 13. PMID 31931712, Free PMC Article
    2. Mutations in LACS2, a long-chain acyl-coenzyme A synthetase, enhance susceptibility to avirulent Pseudomonas syringae but confer resistance to Botrytis cinerea in Arabidopsis. Tang D, et al. Plant Physiol, 2007 Jun. PMID 17434992, Free PMC Article
    3. A permeable cuticle in Arabidopsis leads to a strong resistance to Botrytis cinerea. Bessire M, et al. EMBO J, 2007 Apr 18. PMID 17396154, Free PMC Article
    4. Osmotic regulation of root system architecture. Deak KI, et al. Plant J, 2005 Jul. PMID 15960613
    5. The acyl-CoA synthetase encoded by LACS2 is essential for normal cuticle development in Arabidopsis. Schnurr J, et al. Plant Cell, 2004 Mar. PMID 14973169, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An orthologue of the Arabidopsis LACS2 gene, a long chain acyl-CoA synthetase, BnLACS2, located in the endoplasmic reticulum was identified in B. napus. BnLACS2 transcription increased the expression of genes involved in glycolysis, and FA and lipid synthesis in developing seeds. These results suggested that BnLACS2 is an important factor for seed oil production in B. napus.
      Title: Long-chain acyl-CoA synthetase 2 is involved in seed oil production in Brassica napus.
    2. Both ABA and LRD2 control root system architecture in the presence or absence of osmotic stress in A. thaliana. [LRD2]
      Title: Osmotic regulation of root system architecture.
    3. lacs1 lacs2 double-mutant plants displayed pleiotropic phenotypes including organ fusion, abnormal flower development and reduced seed set.
      Title: Organ fusion and defective cuticle function in a lacs1 lacs2 double mutant of Arabidopsis.
    4. mutant highly resistant to Botrytis cinerea
      Title: Mutations in LACS2, a long-chain acyl-coenzyme A synthetase, enhance susceptibility to avirulent Pseudomonas syringae but confer resistance to Botrytis cinerea in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001333383.1
    NM_103833.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cutin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    long-chain acyl-CoA synthetase 2
    NP_175368.2
    • long-chain acyl-CoA synthetase 2 (LACS2); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT1G64400.1); Has 53337 Blast hits to 50359 proteins in 3209 species: Archae - 917; Bacteria - 34261; Metazoa - 2388; Fungi - 2032; Plants - 1855; Viruses - 1; Other Eukaryotes - 11883 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18290942..18295905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103833.5 → NP_175368.2  long-chain acyl-CoA synthetase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175368.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XIA9
      UniProtKB/TrEMBL
      A0A178W3L9, A0A5S9WNG6, A0A654ESQ6
      Conserved Domains (1) summary
      PLN02861
      Location:3 → 665
      PLN02861; long-chain-fatty-acid-CoA ligase

    2. NM_001333383.1 → NP_001321632.1  long-chain acyl-CoA synthetase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ARJ4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XIA9.1

    Gene LinkOut

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