RECQL2 RECQ helicase L2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RECQL2
Official Full Name: RECQ helicase L2
Primary source: TAIR:AT1G31360
Locus tag: AT1G31360
See related: Araport:AT1G31360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA RECQ 2; ARABIDOPSIS THALIANA RECQ 2; ATRECQ2; MED34; RECQ helicase L2; T19E23.16; T19E23_16
Summary: Encodes a (d)NTP-dependent 3'->5' DNA helicase. This protein can also disrupt D loop structures and may mediate branch migration of Holliday junctions when tested in vitro. The unwinding activity of the enzyme depends on the presence of divalent cations (Mg2+, Mn2+, or Ca2+, but not Zn2+).(d)NTPs are also required with ATP and dATP supporting the greatest amount of DNA unwinding in vitro.
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Genomic context

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See RECQL2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 20

Sequence:: Chromosome: 1; NC_003070.9 (11232318..11237594)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RecQ helicases AtRECQ2 and AtRECQ3 both show highly repetitive DNA unwinding. Although AtRECQ2 preferentially orients itself towards the junction to unwind it, AtRECQ3 moves in the opposite direction and processively rewinds, that is, helps closing, unzipped hairpins over hundreds of bases. Thus RecQ helicases can exhibit antagonistic activities on the molecular level. [RECQ2]
Title: Fork sensing and strand switching control antagonistic activities of RecQ helicases.
AtRECQ2 and AtRECQ3 differ in their requirements for (deoxy)nucleoside triphosphates for strand unwinding and in processing of Holliday junctions.
Title: Biochemical characterization of AtRECQ3 reveals significant differences relative to other RecQ helicases.
AtRECQ2 is a (d)NTP-dependent 3'-->5' DNA helicase. AtRECQ2 is able to disrupt recombinogenic structures by disrupting various D-loop structures
Title: AtRECQ2, a RecQ helicase homologue from Arabidopsis thaliana, is able to disrupt various recombinogenic DNA structures in vitro.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001084170.2

Supported by ESTs:

NM_001332956.1

Supported by ESTs:

NM_001332957.1

Supported by ESTs:

NM_001332958.1

Supported by ESTs:

NM_001332959.1

Supported by ESTs:

NM_001332960.1

Supported by ESTs:

NM_001332961.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA recombination	IC Inferred by Curator more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IC Inferred by Curator more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RECQ helicase L2

NP_001077639.1

RECQ helicase L2 (RECQL2); CONTAINS InterPro DOMAIN/s: RQC domain (InterPro:IPR018982), DNA helicase, ATP-dependent, RecQ type (InterPro:IPR004589), DNA helicase, ATP-dependent, RecQ type, N-terminal (InterPro:IPR018329), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), Helicase/RNase D C-terminal, HRDC domain (InterPro:IPR002121); BEST Arabidopsis thaliana protein match is: DNA helicase (RECQl4A) (TAIR:AT1G10930.1); Has 27972 Blast hits to 27909 proteins in 2839 species: Archae - 320; Bacteria - 17784; Metazoa - 2771; Fungi - 1804; Plants - 1361; Viruses - 12; Other Eukaryotes - 3920 (source: NCBI BLink).

NP_001319121.1

RECQ helicase L2 (RECQL2); CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RQC domain (InterPro:IPR018982), DNA helicase, ATP-dependent, RecQ type (InterPro:IPR004589), DNA helicase, ATP-dependent, RecQ type, N-terminal (InterPro:IPR018329), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), Helicase/RNase D C-terminal, HRDC domain (InterPro:IPR002121); BEST Arabidopsis thaliana protein match is: DNA helicase (RECQl4A) (TAIR:AT1G10930.1); Has 32628 Blast hits to 32552 proteins in 2916 species: Archae - 507; Bacteria - 20337; Metazoa - 3383; Fungi - 2416; Plants - 1613; Viruses - 17; Other Eukaryotes - 4355 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

11232318..11237594

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102875.4 → NP_174421.3 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AV94, A0A654EQ73
NM_001084170.2 → NP_001077639.1 RECQ helicase L2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077639.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WAH8

Conserved Domains (6) summary

COG0514
Location:2 → 541

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

cd00079
Location:158 → 291

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:2 → 136

DEAD; DEAD/DEAH box helicase

pfam00570
Location:475 → 535

HRDC; HRDC domain

pfam16124
Location:296 → 350

RecQ_Zn_bind; RecQ zinc-binding

cl09632
Location:355 → 453

RQC; RQC domain
NM_001332957.1 → NP_001322841.1 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AV97
NM_001332959.1 → NP_001322843.1 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WAH8, A0A1P8AVA5
NM_001332956.1 → NP_001319121.1 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MRK2, Q9FT73, Q9SHE4

UniProtKB/TrEMBL

A0A178WAH8
NM_001332960.1 → NP_001322842.1 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AV65
NM_001332958.1 → NP_001322840.1 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AV98
NM_001332961.1 → NP_001322844.1 RECQ helicase L2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AV97