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    SUDS3 SDS3 homolog, SIN3A corepressor complex component [ Homo sapiens (human) ]

    Gene ID: 64426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SUDS3provided by HGNC
    Official Full Name
    SDS3 homolog, SIN3A corepressor complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:29545
    See related
    Ensembl:ENSG00000111707 MIM:608250; AllianceGenome:HGNC:29545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDS3; SAP45
    Summary
    SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See SUDS3 in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118376555..118418033)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118363824..118405300)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118814360..118855838)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TAO kinase 3 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7110 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118778991-118779218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7111 Neighboring gene uncharacterized LOC124903031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118814415-118814915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7112 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118899925-118900083 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:118950661-118951161 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118988007-118988217 Neighboring gene MPRA-validated peak1995 silencer Neighboring gene Sharpr-MPRA regulatory region 1346 Neighboring gene long intergenic non-protein coding RNA 2460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7113 Neighboring gene ribosomal protein L17 pseudogene 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells. Silveira AC, et al. Cancer Lett, 2009 Apr 8. PMID 19070953, Free PMC Article
    2. Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity. Ramakrishna S, et al. PLoS One, 2012. PMID 22662218, Free PMC Article
    3. TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. Cook-Sather SD, et al. Pain, 2014 Sep. PMID 24909733, Free PMC Article
    4. SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation. Lee DM, et al. Environ Toxicol Pharmacol, 2012 Nov. PMID 22981438
    5. Identification and characterization of three new components of the mSin3A corepressor complex. Fleischer TC, et al. Mol Cell Biol, 2003 May. PMID 12724404, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. studies reveal that loss of FAM60A or another component of the Sin3 complex, SDS3, leads to a change in cell morphology and an increase in cell migration
      Title: Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.
    2. Our results have demonstrated that these hyaluronan binding motifs (HABMs) in USP17 and its substrate SDS3 are mainly involved in the inhibition of anchorage-independent tumor growth.
      Title: Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity.
    3. SDS3, being a substrate of USP17, may play an important role in developing a novel therapeutic means to inhibit specific HDAC activities in cancer.
      Title: Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.
    4. the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors
      Title: Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
    EBI GWAS Catalog
    TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00052, MGC104711

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in substantia nigra development HEP PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sin3 histone deacetylase corepressor complex component SDS3
    Names
    45 kDa Sin3-associated polypeptide
    sin3A-associated protein, 45kDa
    suppressor of defective silencing 3 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022491.3 → NP_071936.2  sin3 histone deacetylase corepressor complex component SDS3

      See identical proteins and their annotated locations for NP_071936.2

      Status: VALIDATED

      Source sequence(s)
      AA916093, AC026367, AK024460, BC098404
      Consensus CDS
      CCDS44993.1
      UniProtKB/Swiss-Prot
      Q4KMQ5, Q8N6H0, Q9H7L9, Q9H8D2
      Related
      ENSP00000443988.1, ENST00000543473.2
      Conserved Domains (1) summary
      pfam08598
      Location:62 → 178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      118376555..118418033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429355.1 → XP_047285311.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

    2. XM_017019817.2 → XP_016875306.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X2

    3. XM_047429356.1 → XP_047285312.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X3

    4. XM_047429357.1 → XP_047285313.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

    5. XM_047429358.1 → XP_047285314.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      118363824..118405300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372898.1 → XP_054228873.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

    2. XM_054372899.1 → XP_054228874.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X2

    3. XM_054372900.1 → XP_054228875.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X3

    4. XM_054372901.1 → XP_054228876.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

    5. XM_054372902.1 → XP_054228877.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H7L9.2 GenPept UniProtKB/Swiss-Prot:Q9H7L9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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