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Envelope surface glycoprotein gp120
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env
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HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages |
PubMed
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env
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Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
PubMed
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env
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HIV-1 gp120 upregulates the expression of interleukin 10 (IL-10) in human B cells |
PubMed
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env
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HIV-1 gp120-expanded CD33+ myeloid derived suppressor cells increase IL-10 production and CD4+/CD25+/FoxP3+ regulatory T-cell levels in T-cell cocultures |
PubMed
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env
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HIV-1 gp120-induced release of IL-10 depends on the activation of Raf-1 along with NF-kappaB p65 in immature dentritic cells |
PubMed
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env
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HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells |
PubMed
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env
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HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells |
PubMed
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env
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HIV-1 gp120 induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL-10, and TNF-alpha in immature dentritic cells |
PubMed
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env
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HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and ERK signaling pathway |
PubMed
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env
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HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells |
PubMed
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env
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HIV-1 gp120-induced reduction of IL-12 parallels IL-10 induction and inhibits translocation of CD40 to the surface of monocytes |
PubMed
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Envelope surface glycoprotein gp160, precursor
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env
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IL-10-producing B cells in HIV-1 infection are enriched for HIV-1 trimeric Env specificity |
PubMed
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env
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HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env |
PubMed
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env
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Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12 |
PubMed
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Envelope transmembrane glycoprotein gp41
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env
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A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-10 in peptide-treated PBMCs |
PubMed
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env
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HIV-1 gp41 induces IL-10 expression in human monocytes and gp41-induced IL-10 expression leads to reduced IL-2 and interferon-gamma production |
PubMed
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env
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Mutations L576A, Q577A, A578G, R579A, E584A, and D589A in the conserved immunosuppressive domain (amino acids 576-589) of HIV-1 gp41 significantly downregulate IL-10 release from human PBMCs |
PubMed
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env
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Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 |
PubMed
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env
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IL-10 inhibits gp41-induced IL-6 production and reduces the expression of IL-6 mRNA |
PubMed
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Nef
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nef
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HIV-1 Nef induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL-10, and TNF-alpha in immature dentritic cells |
PubMed
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nef
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HIV-1 Nef significantly upregulates IL-10 protein and mRNA expression in monocytes but not in T or B lymphocytes; by contrast, SEA induced IL-10 protein and mRNA expression in T lymphocytes but not in monocytes or B lymphocytes |
PubMed
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nef
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HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells |
PubMed
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nef
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HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulating IL-10 production |
PubMed
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nef
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HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors |
PubMed
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nef
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Herbimycin A significantly blocks HIV-1 Nef-induced production of IL-10 at both the protein and the mRNA level, demonstrating the involvement of a herbimycin A-sensitive Protein tyrosine kinase in the signal transduction pathway for exogenous HIV-1 Nef |
PubMed
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nef
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Extracellular HIV-1 Nef induces interleukin (IL)-10 mRNA expression in human PBMCs as well as in H9 T and U937 promonocytic human cell lines; release of IL-10 into supernatants from PBMCs stimulated with Nef is dose-dependent |
PubMed
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Pol
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gag-pol
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HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env |
PubMed
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Pr55(Gag)
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gag
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Expression of IL-10 is significantly upregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs |
PubMed
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gag
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IL-10 production in response to HIV-1 gag stimulation is observed in a subset of CD8(+) T cells with a CD25(-)/ FoxP3(-) phenotype |
PubMed
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gag
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HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IL-10 in a dose and time dependent manner |
PubMed
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gag
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Immunosuppressive peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag upregulate prostaglandin E2 production and induce IL-10 secretion |
PubMed
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Tat
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tat
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HIV-1 Tat activates TLR4, which induces production of TNF and IL10 in human monocytes |
PubMed
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tat
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HIV-1 Tat upregulates expression of IL-10 in peripheral blood monocytes, macrophages, and T-cell lines through a protein kinase C dependent mechanism involving NF-kappa B, ERK1, and ERK2 |
PubMed
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tat
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Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta |
PubMed
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tat
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HIV-1 Tat-induced release of TNF-alpha and IL-10 is TLR4-dependent in monocytes |
PubMed
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tat
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HIV-1 Tat induces production of IL-10 through the activation of PKC beta(II) and delta isozymes in human monocytes and macrophages |
PubMed
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tat
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Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors |
PubMed
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tat
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Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes |
PubMed
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tat
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Ets1- and Sp1-binding sites as specific inducible responsive elements are required for HIV-1 Tat-induced IL-10 promoter activation; Ets-1 is essential for the Tat-induced activation of IL-10 |
PubMed
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tat
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Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) |
PubMed
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tat
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Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 |
PubMed
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tat
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Monocytes treated with HIV-1 clade C Tat show significant upregulation of anti-inflammatory cytokines, IL-4 and IL-10, as compared to clade B Tat-treated cultures |
PubMed
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tat
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The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production |
PubMed
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tat
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IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells |
PubMed
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tat
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IL-10 inhibits HIV-1 gene expression in an HIV-1 Tat-dependent manner by downregulating cyclin T1 expression through the induction of proteasome-mediated proteolysis in human macrophages |
PubMed
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Vif
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vif
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HIV-1 Vif upregulates the expression of interleukin 10 (IL10) in Vif-expression T cells |
PubMed
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Vpr
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vpr
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HIV-1 Vpr upregulates the production of interleukin 10 (IL-10) in dendritic cells |
PubMed
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vpr
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HIV-1 Vpr modulates expression of interleukin 10 (IL-10), increasing or suppressing IL-10 expression through varying effects on NF-kappa B activity in different cell lines |
PubMed
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capsid
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gag
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Immunosuppressive peptides corresponding to HIV-1 Capsid amino acids 218-238 upregulate prostaglandin E2 production and induce IL-10 secretion |
PubMed
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reverse transcriptase
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gag-pol
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IL-10 inhibits HIV-1 replication in primary tissue culture-derived macrophages in a dose-dependent manner, decreases HIV-1 reverse transcription upon macrophage infection, and subsequently mediates viral latency in vitro |
PubMed
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