Lipe lipase, hormone sensitive [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lipeprovided by MGI
Official Full Name: lipase, hormone sensitiveprovided by MGI
Primary source: MGI:MGI:96790
See related: Ensembl:ENSMUSG00000003123 AllianceGenome:MGI:96790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HSL; REH; 4933403G17Rik
Summary: Enables several functions, including lipase activity; retinyl-palmitate esterase activity; and serine hydrolase activity. Involved in diacylglycerol catabolic process and ether lipid metabolic process. Acts upstream of or within cellular response to cold; long-chain fatty acid catabolic process; and triglyceride catabolic process. Located in cytosol; lipid droplet; and membrane. Is expressed in adipose tissue; ileum; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 216.0), mammary gland adult (RPKM 160.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.78 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (25078952..25097911, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25379527..25398486, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reducing the lipase LIPE in mutant alpha-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism.
Title: Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism.
Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL.
Title: Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL.
Genetic deletion of hormone-sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet-induced obesity on memory.
Title: Genetic deletion of hormone-sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet-induced obesity on memory.
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
Title: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity.
Title: Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity.
SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
Title: SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.
Title: Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.
Hormone sensitive lipase ablation promotes bone regeneration.
Title: Hormone sensitive lipase ablation promotes bone regeneration.
Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis.
Title: Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis.
Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.
Title: Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131319 (e-PCR)
- UniSTS:214602

U69543 (e-PCR)
- UniSTS:159612

D1Bda5 (e-PCR)
- UniSTS:240339

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on ester bonds	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA primary transcript binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables retinyl-palmitate esterase activity	ISO Inferred from Sequence Orthology more info
enables serine hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol ester esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to cold	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diacylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diacylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within diacylglycerol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ether lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-chain fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase I transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transcription initiation at RNA polymerase I promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: hormone-sensitive lipase

Names: monoacylglycerol lipase LIPE; retinyl ester hydrolase

NP_001034596.1

EC 3.1.1.23

EC 3.1.1.79

NP_034849.2

EC 3.1.1.23

EC 3.1.1.79

XP_006539633.2

EC 3.1.1.23

EC 3.1.1.79

XP_006539635.1

EC 3.1.1.23

EC 3.1.1.79

XP_030098038.1

EC 3.1.1.23

EC 3.1.1.79

XP_030098040.1

EC 3.1.1.23

EC 3.1.1.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039507.2 → NP_001034596.1 hormone-sensitive lipase isoform 2

See identical proteins and their annotated locations for NP_001034596.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC169209

Consensus CDS

CCDS20982.1

UniProtKB/Swiss-Prot

P54310, P97866, Q3TE34, Q6GU16, Q8CDI9

Related

ENSMUSP00000050935.8, ENSMUST00000054301.14

Conserved Domains (2) summary

pfam06350
Location:6 → 314

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:345 → 493

Abhydrolase; alpha/beta hydrolases
NM_010719.5 → NP_034849.2 hormone-sensitive lipase isoform 1

See identical proteins and their annotated locations for NP_034849.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK029984, BY513432

Consensus CDS

CCDS20981.1

UniProtKB/Swiss-Prot

P54310

Related

ENSMUSP00000003207.5, ENSMUST00000003207.11

Conserved Domains (3) summary

COG0657
Location:378 → 535

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam06350
Location:49 → 357

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:388 → 536

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

25078952..25097911 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539570.2 → XP_006539633.2 hormone-sensitive lipase isoform X1

UniProtKB/TrEMBL

E9Q4M2

Related

ENSMUSP00000123485.2, ENSMUST00000149349.2

Conserved Domains (2) summary

pfam06350
Location:304 → 612

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:643 → 791

Abhydrolase; alpha/beta hydrolases
XM_030242180.1 → XP_030098040.1 hormone-sensitive lipase isoform X2

UniProtKB/Swiss-Prot

P54310, P97866, Q3TE34, Q6GU16, Q8CDI9

Conserved Domains (2) summary

pfam06350
Location:6 → 314

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:345 → 493

Abhydrolase; alpha/beta hydrolases
XM_030242178.1 → XP_030098038.1 hormone-sensitive lipase isoform X2

UniProtKB/Swiss-Prot

P54310, P97866, Q3TE34, Q6GU16, Q8CDI9

Conserved Domains (2) summary

pfam06350
Location:6 → 314

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:345 → 493

Abhydrolase; alpha/beta hydrolases
XM_006539572.4 → XP_006539635.1 hormone-sensitive lipase isoform X2

See identical proteins and their annotated locations for XP_006539635.1

UniProtKB/Swiss-Prot

P54310, P97866, Q3TE34, Q6GU16, Q8CDI9

Related

ENSMUSP00000145665.2, ENSMUST00000206861.2

Conserved Domains (2) summary

pfam06350
Location:6 → 314

HSL_N; Hormone-sensitive lipase (HSL) N-terminus

cl21494
Location:345 → 493

Abhydrolase; alpha/beta hydrolases