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    Kif27 kinesin family member 27 [ Mus musculus (house mouse) ]

    Gene ID: 75050, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kif27provided by MGI
    Official Full Name
    kinesin family member 27provided by MGI
    Primary source
    MGI:MGI:1922300
    See related
    Ensembl:ENSMUSG00000060176 AllianceGenome:MGI:1922300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930517I18Rik
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in cilium assembly. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and ventricular system development. Located in cilium. Is expressed in several structures, including choroid plexus; floor plate; genitourinary system; liver; and spleen. Used to study hydrocephalus. Orthologous to human KIF27 (kinesin family member 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 15.0) and CNS E18 (RPKM 0.7) See more
    Orthologs
    human all
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    Genomic context

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    See Kif27 in Genome Data Viewer
    Location:
    13 B1; 13 30.99 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58432541..58512559, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58284727..58364745, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34674 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene G kinase anchoring protein 1 Neighboring gene STARR-seq mESC enhancer starr_34675 Neighboring gene predicted gene, 26555 Neighboring gene STARR-seq mESC enhancer starr_34676 Neighboring gene STARR-seq mESC enhancer starr_34677 Neighboring gene STARR-seq mESC enhancer starr_34678 Neighboring gene microRNA 6369 Neighboring gene STARR-seq mESC enhancer starr_34680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58474531-58474732 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Katoh Y, et al. Int J Mol Med, 2006 Dec. PMID 17089004
    2. Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. Yue Y, et al. J Cell Biol, 2018 Apr 2. PMID 29351996, Free PMC Article
    3. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Varjosalo M, et al. Dev Cell, 2006 Feb. PMID 16459297
    4. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
    5. The primary cilium as the cell's antenna: signaling at a sensory organelle. Singla V, et al. Science, 2006 Aug 4. PMID 16888132

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF27
    Names
    kinesin-related protein KIF27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360894.1 → NP_001347823.1  kinesin-like protein KIF27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154437, AC163038, AW494673, BC116646
      Conserved Domains (1) summary
      COG1196
      Location:258 → 633
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_175214.4 → NP_780423.2  kinesin-like protein KIF27 isoform 1

      See identical proteins and their annotated locations for NP_780423.2

      Status: VALIDATED

      Source sequence(s)
      AC154437, AC163038, AW494673, BK001056
      Consensus CDS
      CCDS26570.1
      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Related
      ENSMUSP00000043304.6, ENSMUST00000043605.6
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      58432541..58512559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517436.4 → XP_006517499.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517499.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    2. XM_006517433.5 → XP_006517496.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517496.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    3. XM_011244580.4 → XP_011242882.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_011242882.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    4. XM_006517435.4 → XP_006517498.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517498.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    5. XM_036158200.1 → XP_036014093.1  kinesin-like protein KIF27 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:258 → 633
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006517429.4 → XP_006517492.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517492.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    7. XM_011244579.3 → XP_011242881.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_011242881.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    8. XM_017315620.2 → XP_017171109.1  kinesin-like protein KIF27 isoform X1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    9. XM_017315619.2 → XP_017171108.1  kinesin-like protein KIF27 isoform X1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    10. XM_006517431.3 → XP_006517494.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517494.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    11. XM_030247439.1 → XP_030103299.1  kinesin-like protein KIF27 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:258 → 633
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_006517426.3 → XP_006517489.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517489.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Related
      ENSMUSP00000153598.2, ENSMUST00000225388.2
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    13. XM_006517427.3 → XP_006517490.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517490.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    14. XM_006517434.3 → XP_006517497.1  kinesin-like protein KIF27 isoform X1

      See identical proteins and their annotated locations for XP_006517497.1

      UniProtKB/Swiss-Prot
      Q14AX5, Q7M6Z4, Q8BMB9
      Conserved Domains (2) summary
      COG1196
      Location:721 → 1096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    15. XM_017315623.1 → XP_017171112.1  kinesin-like protein KIF27 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:673 → 1048
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    16. XM_017315621.2 → XP_017171110.1  kinesin-like protein KIF27 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:721 → 1077
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    17. XM_017315622.2 → XP_017171111.1  kinesin-like protein KIF27 isoform X3

      Conserved Domains (3) summary
      TIGR00618
      Location:332 → 967
      sbcc; exonuclease SbcC
      COG0419
      Location:678 → 1203
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01372
      Location:4 → 342
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

    RNA

    1. XR_003950487.1 RNA Sequence

    2. XR_001780822.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M6Z4.1 GenPept UniProtKB/Swiss-Prot:Q7M6Z4

    Gene LinkOut

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