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    Cenpx centromere protein X [ Mus musculus (house mouse) ]

    Gene ID: 20892, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cenpxprovided by MGI
    Official Full Name
    centromere protein Xprovided by MGI
    Primary source
    MGI:MGI:894324
    See related
    Ensembl:ENSMUSG00000025144 AllianceGenome:MGI:894324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stra13
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in interstrand cross-link repair; replication fork processing; and resolution of meiotic recombination intermediates. Predicted to be located in chromatin. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. Is expressed in mammary gland epithelium. Orthologous to human CENPX (centromere protein X). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 16.5), adrenal adult (RPKM 12.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpx in Genome Data Viewer
    Location:
    11 E2; 11 84.45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120601768..120604721, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120710941..120713895, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene notum palmitoleoyl-protein carboxylesterase Neighboring gene STARR-seq mESC enhancer starr_31365 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene STARR-positive B cell enhancer ABC_E472 Neighboring gene leucine rich repeat containing 45 Neighboring gene STARR-positive B cell enhancer ABC_E10737 Neighboring gene Rac family small GTPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. St-Pierre B, et al. Gene Expr Patterns, 2004 Dec. PMID 15567721
    2. Stra13 homodimers repress transcription through class B E-box elements. St-Pierre B, et al. J Biol Chem, 2002 Nov 29. PMID 12297495
    3. E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha. Scott LM, et al. Blood, 1996 Oct 1. PMID 8839844
    4. Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. Du X, et al. PLoS One, 2014. PMID 24595170, Free PMC Article
    5. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of meiotic recombination intermediates ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FANCM-MHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FANCM-MHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein X
    Names
    CENP-X
    FANCM-interacting histone fold protein 2
    Fanconi anemia-associated polypeptide of 10 kDa
    immediate-early-response protein D9
    retinoic acid-inducible gene D9 protein
    stimulated by retinoic acid 13
    stimulated by retinoic acid gene 13 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347611.2 → NP_001334540.1  centromere protein X isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663030
      Consensus CDS
      CCDS83948.1
      UniProtKB/Swiss-Prot
      Q8C4X1
      Related
      ENSMUSP00000026137.8, ENSMUST00000026137.8

    2. NM_001347612.2 → NP_001334541.1  centromere protein X isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663030
      Consensus CDS
      CCDS83947.1
      UniProtKB/TrEMBL
      A2AC07
      Related
      ENSMUSP00000101760.2, ENSMUST00000106154.8
      Conserved Domains (1) summary
      pfam09415
      Location:46 → 113
      CENP-X; CENP-S associating Centromere protein X

    3. NM_001425441.1 → NP_001412370.1  centromere protein X isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663030

    4. NM_001425443.1 → NP_001412372.1  centromere protein X isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL663030

    5. NM_001425444.1 → NP_001412373.1  centromere protein X isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL663030

    6. NM_001425445.1 → NP_001412374.1  centromere protein X isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL663030

    7. NM_001425447.1 → NP_001412376.1  centromere protein X isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663030
      UniProtKB/TrEMBL
      A2AC07

    8. NM_001425449.1 → NP_001412378.1  centromere protein X isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL663030

    9. NM_001425451.1 → NP_001412380.1  centromere protein X isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL663030

    10. NM_001425452.1 → NP_001412381.1  centromere protein X isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL663030

    11. NM_001425453.1 → NP_001412382.1  centromere protein X isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL663030

    12. NM_001425454.1 → NP_001412383.1  centromere protein X isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL663030

    13. NM_001425455.1 → NP_001412384.1  centromere protein X isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL663030

    14. NM_001425457.1 → NP_001412386.1  centromere protein X isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL663030

    15. NM_016665.3 → NP_057874.2  centromere protein X isoform 1

      See identical proteins and their annotated locations for NP_057874.2

      Status: VALIDATED

      Source sequence(s)
      AL663030
      Consensus CDS
      CCDS49009.1
      UniProtKB/Swiss-Prot
      A2AC08, O08693, O08694, O08695, Q8BPD7, Q8C4X1
      Related
      ENSMUSP00000050335.7, ENSMUST00000055424.13
      Conserved Domains (1) summary
      pfam09415
      Location:9 → 77
      CENP-X; CENP-S associating Centromere protein X

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120601768..120604721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248853.3 → XP_011247155.2  centromere protein X isoform X6

      Conserved Domains (1) summary
      pfam09415
      Location:89 → 122
      CENP-X; CENP-S associating Centromere protein X

    2. XM_011248850.3 → XP_011247152.2  centromere protein X isoform X3

    3. XM_006532729.3 → XP_006532792.3  centromere protein X isoform X5

    4. XM_011248852.3 → XP_011247154.2  centromere protein X isoform X2

    5. XM_011248848.1 → XP_011247150.1  centromere protein X isoform X1

      See identical proteins and their annotated locations for XP_011247150.1

      Conserved Domains (1) summary
      pfam09415
      Location:46 → 79
      CENP-X; CENP-S associating Centromere protein X
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4X1.1 GenPept UniProtKB/Swiss-Prot:Q8C4X1

    Gene LinkOut

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