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    pank4 pantothenate kinase 4 (inactive) [ Danio rerio (zebrafish) ]

    Gene ID: 393487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pank4provided by ZNC
    Official Full Name
    pantothenate kinase 4 (inactive)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1592
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040426-1592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66285
    Summary
    Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pank4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (15878343..15915789)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (15743708..15781154)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496681 Neighboring gene RAP1A, member of RAS oncogene family b Neighboring gene dorsal inhibitory axon guidance protein a Neighboring gene zgc:173544

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease. Zizioli D, et al. Neurobiol Dis, 2016 Jan. PMID 26476142, Free PMC Article
    2. Neucrin, a novel secreted antagonist of canonical Wnt signaling, plays roles in developing neural tissues in zebrafish. Miyake A, et al. Mech Dev, 2012 Jan-Feb. PMID 22265871
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66285

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantothenate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4'-phosphopantetheine phosphatase
    NP_001315316.1
    XP_005155852.1
    XP_005155853.1
    XP_068080227.1
    XP_068080228.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328387.1 → NP_001315316.1  4'-phosphopantetheine phosphatase

      Status: VALIDATED

      Source sequence(s)
      FP003590
      UniProtKB/TrEMBL
      A0A8M1P4R1, A0A8M3BDL0
      Conserved Domains (3) summary
      PLN02902
      Location:3 → 775
      PLN02902; pantothenate kinase
      pfam01937
      Location:453 → 766
      DUF89; Protein of unknown function DUF89
      pfam03630
      Location:35 → 364
      Fumble; Fumble

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      15878343..15915789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155795.5 → XP_005155852.1  4'-phosphopantetheine phosphatase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2I2, A0A8M3BDL0
      Conserved Domains (3) summary
      PLN02902
      Location:3 → 773
      PLN02902; pantothenate kinase
      pfam01937
      Location:451 → 764
      DUF89; Protein of unknown function DUF89
      pfam03630
      Location:35 → 364
      Fumble; Fumble

    2. XM_005155796.5 → XP_005155853.1  4'-phosphopantetheine phosphatase isoform X2

      UniProtKB/TrEMBL
      A0A8M2B1X9, A0A8M3BDL0
      Conserved Domains (3) summary
      PLN02902
      Location:3 → 769
      PLN02902; pantothenate kinase
      pfam01937
      Location:447 → 760
      DUF89; Protein of unknown function DUF89
      pfam03630
      Location:35 → 360
      Fumble; Fumble

    3. XM_068224126.1 → XP_068080227.1  4'-phosphopantetheine phosphatase isoform X3

      UniProtKB/TrEMBL
      A0A8M3AXH7

    4. XM_068224127.1 → XP_068080228.1  4'-phosphopantetheine phosphatase isoform X4

      UniProtKB/TrEMBL
      A0A8M3B6T9

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394809.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      51060..88506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200515.1: Suppressed sequence

      Description
      NM_200515.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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