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    smox spermine oxidase [ Danio rerio (zebrafish) ]

    Gene ID: 387290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smoxprovided by ZNC
    Official Full Name
    spermine oxidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031201-3
    See related
    Ensembl:ENSDARG00000036967 AllianceGenome:ZFIN:ZDB-GENE-031201-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb1027; zgc:77167; wu:fq32f10
    Summary
    Predicted to enable polyamine oxidase activity. Acts upstream of or within hemopoiesis. Predicted to be active in cytoplasm. Is expressed in several structures, including anterior axial hypoblast; blood vessel; mesoderm; nervous system; and pancreatic system. Orthologous to human SMOX (spermine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See smox in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (41849152..41865986)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (41147988..41164822)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene F-box protein 41 Neighboring gene ring finger protein 24 Neighboring gene si:dkey-37g12.1 Neighboring gene 5-hydroxytryptamine receptor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo. Herzog C, et al. Biol Open, 2020 May 4. PMID 32366533, Free PMC Article
    2. Identification and characterization of a specific 13-miRNA expression signature during follicle activation in the zebrafish ovary. Wong QW, et al. Biol Reprod, 2018 Jan 1. PMID 29228146
    3. The Zebrafish Insertion Collection (ZInC): a web based, searchable collection of zebrafish mutations generated by DNA insertion. Varshney GK, et al. Nucleic Acids Res, 2013 Jan. PMID 23180778, Free PMC Article
    4. Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Tijssen MR, et al. Dev Cell, 2011 May 17. PMID 21571218, Free PMC Article
    5. Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Menon T, et al. Dev Biol, 2020 Dec 1. PMID 32937161

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spermine oxidase
    NP_001315115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328186.1 → NP_001315115.1  spermine oxidase

      Status: VALIDATED

      Source sequence(s)
      BX004888
      UniProtKB/TrEMBL
      A0A8M1PA21, B8A458
      Related
      ENSDARP00000053684.4, ENSDART00000053685.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      41849152..41865986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201502.1: Suppressed sequence

      Description
      NM_201502.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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