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    DLX6 distal-less homeobox 6 [ Homo sapiens (human) ]

    Gene ID: 1750, updated on 10-Dec-2024

    Summary

    Official Symbol
    DLX6provided by HGNC
    Official Full Name
    distal-less homeobox 6provided by HGNC
    Primary source
    HGNC:HGNC:2919
    See related
    Ensembl:ENSG00000006377 MIM:600030; AllianceGenome:HGNC:2919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 2.2), placenta (RPKM 2.1) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DLX6 in Genome Data Viewer
    Location:
    7q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (97005553..97011040)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (98235210..98240696)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (96634865..96640352)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene 5K-Del enhancer in SHFM1 region Neighboring gene uncharacterized LOC124901703 Neighboring gene RNA, 7SL, cytoplasmic 252, pseudogene Neighboring gene DLX6 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96621779-96622304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96622305-96622831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96627585-96628528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:96630843-96631552 Neighboring gene VISTA enhancer hs298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18385 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:96650255-96651454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96653649-96654365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:96655292-96655807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26299 Neighboring gene distal-less homeobox 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:96727665-96727870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26301 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:96763667-96763818 Neighboring gene succinate dehydrogenase complex assembly factor 3 Neighboring gene high mobility group box 3 pseudogene 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-05-14)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-05-14)

    ClinGen Genome Curation Page

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125282, MGC125283, MGC125284, MGC125285

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in anatomical structure formation involved in morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in head development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein DLX-6
    Names
    distal-less homeo box 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005222.4NP_005213.3  homeobox protein DLX-6

      See identical proteins and their annotated locations for NP_005213.3

      Status: REVIEWED

      Source sequence(s)
      AC004774, AK094086, BU616500
      Consensus CDS
      CCDS47647.2
      UniProtKB/Swiss-Prot
      P56179
      Related
      ENSP00000428480.2, ENST00000518156.3
      Conserved Domains (2) summary
      COG5576
      Location:119231
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:170223
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      97005553..97011040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      98235210..98240696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)