U.S. flag

An official website of the United States government

Links from Nucleotide

    • Showing Current items.

    NTS neurotensin [ Homo sapiens (human) ]

    Gene ID: 4922, updated on 10-Dec-2024

    Summary

    Official Symbol
    NTSprovided by HGNC
    Official Full Name
    neurotensinprovided by HGNC
    Primary source
    HGNC:HGNC:8038
    See related
    Ensembl:ENSG00000133636 MIM:162650; AllianceGenome:HGNC:8038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NN; NT; NT/N; NTS1; NMN-125
    Summary
    This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in small intestine (RPKM 86.5), stomach (RPKM 27.6) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NTS in Genome Data Viewer
    Location:
    12q21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (85874295..85882992)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (85854932..85863806)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (86268073..86276770)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 3 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:86176139-86177338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:86236994-86237738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:86237739-86238483 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:86257241-86257374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4690 Neighboring gene Ras association domain family member 9 Neighboring gene MGAT4 family member C Neighboring gene uncharacterized LOC105369877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:86658073-86658756 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:86692822-86692976 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:86878577-86879202 Neighboring gene microRNA 3059

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide hormone activity  
    enables neuropeptide receptor binding PubMed 
    enables protein binding PubMed 
    enables receptor ligand activity PubMed 
    Component Evidence Code Pubs
    is_active_in axon terminus  
    located_in extracellular region  
    located_in intracellular membrane-bounded organelle  
    located_in transport vesicle  

    General protein information

    Preferred Names
    neurotensin/neuromedin N
    Names
    pro-neurotensin/neuromedin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047010.1 RefSeqGene

      Range
      5001..13698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006183.5NP_006174.1  neurotensin/neuromedin N preproprotein

      See identical proteins and their annotated locations for NP_006174.1

      Status: REVIEWED

      Source sequence(s)
      AF157682, AK312066
      Consensus CDS
      CCDS9029.1
      UniProtKB/Swiss-Prot
      P30990
      UniProtKB/TrEMBL
      Q6FH20
      Related
      ENSP00000256010.5, ENST00000256010.7
      Conserved Domains (1) summary
      pfam07421
      Location:4169
      Pro-NT_NN; Neurotensin/neuromedin N precursor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      85874295..85882992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      85854932..85863806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.