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    CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 282161, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CACNB4provided by VGNC
    Official Full Name
    calcium voltage-gated channel auxiliary subunit beta 4provided by VGNC
    Primary source
    VGNC:VGNC:55329
    See related
    Ensembl:ENSBTAG00000002297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CACNB4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (44070320..44351469)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342971 Neighboring gene signal transducing adaptor molecule 2 Neighboring gene uncharacterized LOC112442569 Neighboring gene ADP ribosylation factor like GTPase 5A Neighboring gene nebulin Neighboring gene uncharacterized LOC112442618

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Greater diversity than previously thought of chromaffin cell Ca2+ channels, derived from mRNA identification studies. García-Palomero E, et al. FEBS Lett, 2000 Sep 22. PMID 11007970
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-4
    Names
    calcium channel, voltage-dependent, beta 4 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192104.1 → NP_001179033.1  voltage-dependent L-type calcium channel subunit beta-4

      See identical proteins and their annotated locations for NP_001179033.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      A0AAA9SCF4, A0AAA9TKI4
      Related
      ENSBTAP00000079920.1, ENSBTAT00000134706.1
      Conserved Domains (3) summary
      cd12043
      Location:91 → 158
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:50 → 91
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:218 → 398
      Guanylate_kin; Guanylate kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44070320..44351469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202405.5 → XP_005202462.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X1

      See identical proteins and their annotated locations for XP_005202462.1

      UniProtKB/TrEMBL
      A0AAA9TC43, A0AAA9TKI4
      Related
      ENSBTAP00000094287.1, ENSBTAT00000090222.1
      Conserved Domains (3) summary
      cd12043
      Location:73 → 140
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam00625
      Location:200 → 380
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:32 → 73
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    2. XM_059891742.1 → XP_059747725.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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