FOXP1 forkhead box P1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOXP1provided by HGNC
Official Full Name: forkhead box P1provided by HGNC
Primary source: HGNC:HGNC:3823
See related: Ensembl:ENSG00000114861 MIM:605515; AllianceGenome:HGNC:3823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MFH; QRF1; 12CC4; hFKH1B; HSPC215
Summary: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p13

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (70954708..71583978, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (70991208..71623253, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (71003859..71633129, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
Title: A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1.
Title: Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1.
The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer.
Title: The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer.
NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
Title: NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.
Title: FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells.
Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.
Title: miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts.
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.
Title: Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging.
FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
Title: FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression.
Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy.
Title: Transcription factor FOXP1 mediates vascular endothelial dysfunction in diabetic retinopathy.

Submit: New GeneRIF Correction See all GeneRIFs (187)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability-severe speech delay-mild dysmorphism syndrome MedGen: C4013764 OMIM: 613670 GeneReviews: FOXP1 Syndrome	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2020-01-22) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2020-01-22) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study and meta-analysis of intraocular pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed
Impact of ancestry and common genetic variants on QT interval in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S1562 (e-PCR), detects polymorphism
- UniSTS:88329

WI-11225 (e-PCR)
- UniSTS:69898

WI-17022 (e-PCR)
- UniSTS:10252

STS-H63744 (e-PCR)
- UniSTS:50447

D3S3533 (e-PCR)
- UniSTS:19218

SHGC-37104 (e-PCR)
- UniSTS:53522

GDB:434012 (e-PCR)
- UniSTS:157204

RH123539 (e-PCR)
- UniSTS:135960

D3S4159 (e-PCR)
- UniSTS:51738

WI-16704 (e-PCR)
- UniSTS:39967

SHGC-56612 (e-PCR)
- UniSTS:94497

STS-T93311 (e-PCR)
- UniSTS:39713

D3S4146 (e-PCR)
- UniSTS:21292

STS-W89007 (e-PCR)
- UniSTS:34622

RH65612 (e-PCR)
- UniSTS:16964

RH80573 (e-PCR)
- UniSTS:86089

SHGC-77096 (e-PCR)
- UniSTS:33098

RH121374 (e-PCR)
- UniSTS:134220

D7S2067E (e-PCR)
- UniSTS:151120

G32747 (e-PCR)
- UniSTS:117328

RH123599 (e-PCR)
- UniSTS:136019

RH80112 (e-PCR)
- UniSTS:85844

D3S1562 (e-PCR), detects polymorphism
- UniSTS:14167

L18426 (e-PCR)
- UniSTS:34648

SHGC-77090 (e-PCR)
- UniSTS:47961

SHGC-77088 (e-PCR)
- UniSTS:30817

D3S659 (e-PCR)
- UniSTS:38244

RH46320 (e-PCR)
- UniSTS:26470

D1S1423 (e-PCR)
- UniSTS:149619

A009P35 (e-PCR)
- UniSTS:9595

RH124072 (e-PCR)
- UniSTS:138882

D3S1210 (e-PCR)
- UniSTS:54162

SHGC-77108 (e-PCR)
- UniSTS:3478

SHGC-17103 (e-PCR)
- UniSTS:30617

SGC30239 (e-PCR)
- UniSTS:1693

RH123202 (e-PCR)
- UniSTS:135584

REN159M20 (e-PCR)
- UniSTS:264360

WI-17713 (e-PCR)
- UniSTS:47790

RH102611 (e-PCR)
- UniSTS:96945

L18441 (e-PCR)
- UniSTS:71348

RH12371 (e-PCR)
- UniSTS:52150

SHGC-77081 (e-PCR)
- UniSTS:67770

RH94234 (e-PCR)
- UniSTS:86203

D3S3568 (e-PCR), detects polymorphism
- UniSTS:13759

SGC34626 (e-PCR)
- UniSTS:46794

SHGC-106545 (e-PCR)
- UniSTS:169936

RH44896 (e-PCR)
- UniSTS:75480

SHGC-152998 (e-PCR)
- UniSTS:177626

RH80601 (e-PCR)
- UniSTS:88796

D15S1390 (e-PCR)
- UniSTS:474340

STS-W89007 (e-PCR)
- UniSTS:23529

RH119312 (e-PCR)
- UniSTS:133874

RH80682 (e-PCR)
- UniSTS:90099

RH102172 (e-PCR)
- UniSTS:96506

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T follicular helper cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in monocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in osteoclast development	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-21 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemokine (C-X-C motif) ligand 2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endothelial tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in striatum development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box protein P1

Names: fork head-related protein like B; glutamine-rich factor 1; mac-1-regulated forkhead

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028243.1 RefSeqGene

Range

5262..634282

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001012505.2 → NP_001012523.1 forkhead box protein P1 isoform b

See identical proteins and their annotated locations for NP_001012523.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate exon in the 3' end, compared to variant 1. The encoded isoform b (previously called isoform 2) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AC097634, BC005055, BC068481

Consensus CDS

CCDS33785.1

UniProtKB/Swiss-Prot

Q9H334

Related

ENSP00000318721.3, ENST00000318779.7
NM_001244808.3 → NP_001231737.1 forkhead box protein P1 isoform c

See identical proteins and their annotated locations for NP_001231737.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c, previously called 3) has the same N- and C-termini but is 1 aa shorter compared to isoform a.

Source sequence(s)

AC103586, AK122710, BC068481, GD144178

Consensus CDS

CCDS58839.1

UniProtKB/TrEMBL

Q8TEA2

Related

ENSP00000418524.1, ENST00000493089.7

Conserved Domains (3) summary

COG5025
Location:437 → 650

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:463 → 544

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001244810.2 → NP_001231739.1 forkhead box protein P1 isoform d

See identical proteins and their annotated locations for NP_001231739.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon but contains another compared to variant 1. The resulting isoform (d, previously called 4) has the same N- and C-termini but is longer compared to isoform a. This variant encodes the longest isoform, which has been shown to enhance embryonic stem (ES) cell pluripotency and repress ES cell differentiation.

Source sequence(s)

AC097634, AC103586, AK122710, BC054505, BC068481, GD144178

Consensus CDS

CCDS74964.1

UniProtKB/TrEMBL

Q8TEA2

Related

ENSP00000498110.1, ENST00000648426.1

Conserved Domains (2) summary

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cl00061
Location:464 → 545

FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins
NM_001244812.3 → NP_001231741.1 forkhead box protein P1 isoform e

See identical proteins and their annotated locations for NP_001231741.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (e, previously called 5) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AA380962, AC103586, AC104442, AK092383, GD144178

Consensus CDS

CCDS58838.1

UniProtKB/TrEMBL

Q8TEA2

Related

ENSP00000417857.1, ENST00000484350.5

Conserved Domains (3) summary

COG5025
Location:361 → 575

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:226 → 293

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:388 → 469

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001244813.3 → NP_001231742.1 forkhead box protein P1 isoform f

See identical proteins and their annotated locations for NP_001231742.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f, previously called 6) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC097632, AC103586, AK074569, GD144178

Consensus CDS

CCDS74963.1

UniProtKB/TrEMBL

A0A3B3IT66, B4DMV4

Related

ENSP00000497567.1, ENST00000650387.1

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:364 → 445

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001244814.3 → NP_001231743.1 forkhead box protein P1 isoform a

See identical proteins and their annotated locations for NP_001231743.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).

Source sequence(s)

AC097632, AC103586, AK074321, DA518749, GD144178

Consensus CDS

CCDS2914.1

UniProtKB/Swiss-Prot

A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1

UniProtKB/TrEMBL

A0A024R346, Q548T7, Q8TEA2

Related

ENSP00000418102.1, ENST00000498215.7

Conserved Domains (3) summary

COG5025
Location:437 → 651

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:464 → 545

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001244815.2 → NP_001231744.2 forkhead box protein P1 isoform f

Status: REVIEWED

Source sequence(s)

AC103586, AK027264, DA634017, GD144178

Consensus CDS

CCDS74963.1

UniProtKB/TrEMBL

A0A3B3IT66, B4DMV4

Related

ENSP00000497077.3, ENST00000648748.3

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:364 → 445

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001244816.2 → NP_001231745.1 forkhead box protein P1 isoform a

See identical proteins and their annotated locations for NP_001231745.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).

Source sequence(s)

AC103586, AF250920, GD144178

Consensus CDS

CCDS2914.1

UniProtKB/Swiss-Prot

A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1

UniProtKB/TrEMBL

A0A024R346, Q548T7, Q8TEA2

Related

ENSP00000497344.1, ENST00000648380.1

Conserved Domains (3) summary

COG5025
Location:437 → 651

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:464 → 545

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349337.2 → NP_001336266.2 forkhead box protein P1 isoform i

Status: REVIEWED

Source sequence(s)

AC097632, AC103586

Consensus CDS

CCDS93310.1

UniProtKB/TrEMBL

A0A0B4J2F3, A0A5H1ZRR8, B4DMV4

Related

ENSP00000420736.3, ENST00000491238.8

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349338.3 → NP_001336267.1 forkhead box protein P1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variants 1, 7, 9, and 13, encodes isoform a.

Source sequence(s)

AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

Consensus CDS

CCDS2914.1

UniProtKB/Swiss-Prot

A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1

UniProtKB/TrEMBL

A0A024R346, Q548T7, Q8TEA2

Related

ENSP00000497369.1, ENST00000649528.3

Conserved Domains (3) summary

COG5025
Location:437 → 651

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:464 → 545

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349340.3 → NP_001336269.1 forkhead box protein P1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 1, 7, 9, and 11 encodes isoform a.

Source sequence(s)

AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

Consensus CDS

CCDS2914.1

UniProtKB/Swiss-Prot

A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1

UniProtKB/TrEMBL

A0A024R346, Q548T7, Q8TEA2

Related

ENSP00000496990.1, ENST00000649631.1

Conserved Domains (3) summary

COG5025
Location:437 → 651

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:464 → 545

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349341.3 → NP_001336270.1 forkhead box protein P1 isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (14) encodes isoform j.

Source sequence(s)

AC097632, AC097634, AC103586, AC104442, AC104645, AC138058

Consensus CDS

CCDS93312.1

UniProtKB/TrEMBL

A0A3B3IST0, Q8TEA2

Related

ENSP00000497693.2, ENST00000649610.2

Conserved Domains (3) summary

COG5025
Location:436 → 650

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:301 → 368

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:463 → 544

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349342.3 → NP_001336271.1 forkhead box protein P1 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variant 6, encodes isoform f.

Source sequence(s)

AC097632, AC103586

Consensus CDS

CCDS74963.1

UniProtKB/TrEMBL

A0A3B3IT66, B4DMV4

Related

ENSP00000496968.1, ENST00000649592.1

Conserved Domains (3) summary

COG5025
Location:337 → 551

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:364 → 445

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349343.3 → NP_001336272.1 forkhead box protein P1 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variant 17, encodes isoform i.

Source sequence(s)

AC097632, AC103586

Consensus CDS

CCDS93310.1

UniProtKB/TrEMBL

A0A0B4J2F3, A0A5H1ZRR8, B4DMV4

Related

ENSP00000497435.1, ENST00000648794.2

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001349344.3 → NP_001336273.1 forkhead box protein P1 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (17), as well as variant 16, encodes isoform i.

Source sequence(s)

AC097632, AC103586

Consensus CDS

CCDS93310.1

UniProtKB/TrEMBL

A0A0B4J2F3, A0A5H1ZRR8, B4DMV4

Related

ENSP00000482847.2, ENST00000614176.5

Conserved Domains (3) summary

COG5025
Location:336 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:201 → 268

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_001370548.1 → NP_001357477.1 forkhead box protein P1 isoform k

Status: REVIEWED

Source sequence(s)

AC097632, AC103586

Consensus CDS

CCDS93311.1

UniProtKB/TrEMBL

A0A3B3IRW5, A0A3B3IS20, B4DMV4

Related

ENSP00000496841.3, ENST00000649695.3

Conserved Domains (3) summary

COG5025
Location:337 → 550

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:202 → 269

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:363 → 444

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)
NM_032682.6 → NP_116071.2 forkhead box protein P1 isoform a

See identical proteins and their annotated locations for NP_116071.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a (previously called isoform 1). Variants 1, 7, 9, 11 and 13 all encode the same isoform (a).

Source sequence(s)

AC097634, AC103586, AK122710, BC068481

Consensus CDS

CCDS2914.1

UniProtKB/Swiss-Prot

A3QVP8, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9H334, Q9P0R1

UniProtKB/TrEMBL

A0A024R346, Q548T7, Q8TEA2

Related

ENSP00000318902.5, ENST00000318789.11

Conserved Domains (3) summary

COG5025
Location:437 → 651

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:302 → 369

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:464 → 545

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)