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    TRIM2 tripartite motif containing 2 [ Homo sapiens (human) ]

    Gene ID: 23321, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TRIM2provided by HGNC
    Official Full Name
    tripartite motif containing 2provided by HGNC
    Primary source
    HGNC:HGNC:15974
    See related
    Ensembl:ENSG00000109654 MIM:614141; AllianceGenome:HGNC:15974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMT2R; RNF86
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Expression
    Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM2 in Genome Data Viewer
    Location:
    4q31.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153152163..153339317)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156476134..156663746)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154073315..154260469)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15754 Neighboring gene Sharpr-MPRA regulatory region 8192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153877563-153878382 Neighboring gene uncharacterized LOC729870 Neighboring gene family with sequence similarity 192, member A pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:153892920-153894119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153894208-153894728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153894729-153895248 Neighboring gene FH2 domain containing 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:153912200-153913399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:153913429-153913928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153942327-153943122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153944769-153945310 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:153949611-153950259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154028483-154028983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154033423-154033922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154057659-154058160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15755 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154127146-154128051 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154130352-154131177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154143059-154143560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154159939-154160440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154160441-154160940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154162218-154162718 Neighboring gene uncharacterized LOC105377496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154178381-154179026 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:154180767-154181283 Neighboring gene RNA, U6 small nuclear 1196, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene meiotic nuclear divisions 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene transmembrane 131 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal NHL domain of human TRIM2. Guan X, et al. Acta Crystallogr F Struct Biol Commun, 2014 May. PMID 24817735, Free PMC Article
    2. TRIM2 is a novel promoter of human colorectal cancer. Cao H, et al. Scand J Gastroenterol, 2019 Feb. PMID 30916596
    3. TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma. Qin Y, et al. Int J Oncol, 2018 Oct. PMID 30066883
    4. Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis. Sun Q, et al. Oncogene, 2020 Oct. PMID 32929153
    5. Gene expression-phenotype associations in adults with eosinophilic esophagitis. Dellon ES, et al. Dig Liver Dis, 2018 Aug. PMID 29628359, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
      Title: Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
    2. Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
      Title: Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
    3. Expression and Role of TRIM2 in Human Diseases.
      Title: Expression and Role of TRIM2 in Human Diseases.
    4. Knockdown of long noncoding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA3693p/TRIM2 axis.
      Title: Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis.
    5. Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.
      Title: Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.
    6. Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
      Title: Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
    7. TRIM2 expression was significantly higher in colorectal cancer tissues than in non-cancerous tissues and was significantly associated with some clinicopathological factors. The results indicate that TRIM2 is a novel promoter of human colorectal cancer.
      Title: TRIM2 is a novel promoter of human colorectal cancer.
    8. TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
      Title: TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
    9. Study revealed that TRIM2 performs important functions in regulating the development and metastasis of osteosarcoma.
      Title: TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma.
    10. TRIM2 is associated with clinical fibrotic phenotypes of eosinophilic esophagitis.
      Title: Gene expression-phenotype associations in adults with eosinophilic esophagitis.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Charcot-Marie-Tooth disease type 2R
    MedGen: C3809655 OMIM: 615490 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of severity in multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of tripartite motif containing 2 (TRIM2) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0517

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tripartite motif-containing protein 2
    Names
    Charcot-Marie-Tooth disease, type 2R
    E3 ubiquitin-protein ligase TRIM2
    RING finger protein 86
    RING-type E3 ubiquitin transferase TRIM2
    tripartite motif protein TRIM2
    NP_001123539.1
    NP_001289621.1
    NP_001289622.1
    NP_001289623.1
    NP_001337983.1
    NP_001337984.1
    NP_001337985.1
    NP_001337986.1
    NP_001362417.1
    NP_001362418.1
    NP_001362419.1
    NP_001362420.1
    NP_001362441.1
    NP_001362442.1
    NP_001362443.1
    NP_001362444.1
    NP_001362445.1
    NP_001362446.1
    NP_001362448.1
    NP_001362449.1
    NP_001362451.1
    NP_001362452.1
    NP_001362454.1
    NP_056086.2
    XP_006714220.1
    XP_006714221.1
    XP_006714228.1
    XP_011530098.1
    XP_016863432.1
    XP_016863437.1
    XP_016863442.1
    XP_047305905.1
    XP_047305907.1
    XP_047305908.1
    XP_047305909.1
    XP_047305910.1
    XP_054205458.1
    XP_054205459.1
    XP_054205460.1
    XP_054205461.1
    XP_054205462.1
    XP_054205463.1
    XP_054205464.1
    XP_054205465.1
    XP_054205466.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041788.1 RefSeqGene

      Range
      56326..191200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130067.2 → NP_001123539.1  tripartite motif-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001123539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate splice site, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB011089, AC114791, AL110178, BC011052
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000415812.2, ENST00000437508.7
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    2. NM_001302692.2 → NP_001289621.1  tripartite motif-containing protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AW071795, BC025417, DA631098
      UniProtKB/TrEMBL
      A0A0J9YW70, A0A0J9YXY2, C9JVI3
      Conserved Domains (1) summary
      cd00162
      Location:50 → 93
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_001302693.2 → NP_001289622.1  tripartite motif-containing protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC025417, DA407606, DA631098
      UniProtKB/TrEMBL
      A0A0J9YW70, A0A0J9YXY2, C9JVI3
      Conserved Domains (1) summary
      cd00162
      Location:49 → 92
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    4. NM_001302694.2 → NP_001289623.1  tripartite motif-containing protein 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains alternate 5' and 3' terminal exons and lacks several other 3' exons, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (5) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      BC025417, DA310963
      Consensus CDS
      CCDS93654.1
      UniProtKB/TrEMBL
      A0A0J9YW02, A0A0J9YW70, A0A0J9YXY2, C9JVI3
      Related
      ENSP00000487750.2, ENST00000482578.3
      Conserved Domains (1) summary
      cd00162
      Location:41 → 84
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    5. NM_001351054.2 → NP_001337983.1  tripartite motif-containing protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791, AI695362
      Consensus CDS
      CCDS93653.1
      UniProtKB/TrEMBL
      A0A6Q8PF74, A0A6Q8PFX3
      Related
      ENSP00000501672.1, ENST00000674935.1
      Conserved Domains (6) summary
      smart00502
      Location:179 → 305
      BBC; B-Box C-terminal domain
      smart00557
      Location:343 → 439
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:24 → 127
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:489 → 766
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:38 → 83
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:133 → 174
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    6. NM_001351055.2 → NP_001337984.1  tripartite motif-containing protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791, AI695362
      Consensus CDS
      CCDS93655.1
      UniProtKB/TrEMBL
      A0A6Q8PFX3, A0A6Q8PGG4
      Related
      ENSP00000502266.1, ENST00000674726.1
      Conserved Domains (6) summary
      smart00502
      Location:178 → 304
      BBC; B-Box C-terminal domain
      smart00336
      Location:130 → 171
      BBOX; B-Box-type zinc finger
      smart00557
      Location:342 → 438
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:488 → 765
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:37 → 82
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cl28410
      Location:23 → 126
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    7. NM_001351056.2 → NP_001337985.1  tripartite motif-containing protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791, AI695362
      Consensus CDS
      CCDS93656.1
      UniProtKB/TrEMBL
      A0A6Q8PFX3, A0A6Q8PG16
      Related
      ENSP00000502077.1, ENST00000676408.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    8. NM_001351057.2 → NP_001337986.1  tripartite motif-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791, AI695362
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Conserved Domains (4) summary
      smart00502
      Location:36 → 162
      BBC; B-Box C-terminal domain
      smart00336
      Location:1 → 29
      BBOX; B-Box-type zinc finger
      smart00557
      Location:200 → 296
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:346 → 619
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

    9. NM_001375488.1 → NP_001362417.1  tripartite motif-containing protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      UniProtKB/TrEMBL
      A0A6Q8PEY7
      Related
      ENSP00000502083.1, ENST00000675673.1
      Conserved Domains (6) summary
      smart00502
      Location:219 → 345
      BBC; B-Box C-terminal domain
      smart00557
      Location:383 → 479
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:33 → 136
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:529 → 802
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:47 → 92
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cl00034
      Location:142 → 214
      Bbox_SF; B-box-type zinc finger superfamily

    10. NM_001375489.1 → NP_001362418.1  tripartite motif-containing protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      UniProtKB/TrEMBL
      A0A6Q8PEY7
      Related
      ENSP00000501562.1, ENST00000675063.1
      Conserved Domains (6) summary
      smart00502
      Location:218 → 344
      BBC; B-Box C-terminal domain
      smart00557
      Location:382 → 478
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:32 → 135
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:528 → 801
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:46 → 91
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cl00034
      Location:141 → 213
      Bbox_SF; B-box-type zinc finger superfamily

    11. NM_001375490.1 → NP_001362419.1  tripartite motif-containing protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      UniProtKB/TrEMBL
      A0A6Q8PGE9
      Related
      ENSP00000502541.1, ENST00000675780.1
      Conserved Domains (6) summary
      smart00502
      Location:188 → 295
      BBC; B-Box C-terminal domain
      smart00557
      Location:333 → 429
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:33 → 136
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:479 → 752
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:47 → 92
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:142 → 183
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    12. NM_001375491.1 → NP_001362420.1  tripartite motif-containing protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      UniProtKB/TrEMBL
      A0A6Q8PGE9
      Related
      ENSP00000502290.1, ENST00000675340.1
      Conserved Domains (6) summary
      smart00502
      Location:187 → 294
      BBC; B-Box C-terminal domain
      smart00557
      Location:332 → 428
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:32 → 135
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:478 → 751
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:46 → 91
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:141 → 182
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    13. NM_001375512.1 → NP_001362441.1  tripartite motif-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000502356.1, ENST00000674976.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    14. NM_001375513.1 → NP_001362442.1  tripartite motif-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000502676.1, ENST00000675315.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    15. NM_001375514.1 → NP_001362443.1  tripartite motif-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000501662.1, ENST00000675745.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    16. NM_001375515.1 → NP_001362444.1  tripartite motif-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000501994.1, ENST00000676458.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    17. NM_001375516.1 → NP_001362445.1  tripartite motif-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000502543.1, ENST00000675054.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    18. NM_001375517.1 → NP_001362446.1  tripartite motif-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS47147.1
      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000501612.1, ENST00000676423.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    19. NM_001375519.1 → NP_001362448.1  tripartite motif-containing protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      UniProtKB/TrEMBL
      A0A6Q8PF82
      Related
      ENSP00000502492.1, ENST00000675425.1
      Conserved Domains (4) summary
      smart00502
      Location:112 → 203
      BBC; B-Box C-terminal domain
      smart00557
      Location:241 → 337
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:387 → 660
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:42 → 92
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

    20. NM_001375520.1 → NP_001362449.1  tripartite motif-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      UniProtKB/TrEMBL
      A0A6Q8PF82
      Related
      ENSP00000502720.1, ENST00000675492.1
      Conserved Domains (4) summary
      smart00502
      Location:111 → 202
      BBC; B-Box C-terminal domain
      smart00557
      Location:240 → 336
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:386 → 659
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:46 → 91
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

    21. NM_001375522.1 → NP_001362451.1  tripartite motif-containing protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS93657.1
      UniProtKB/TrEMBL
      A0A6Q8PFB0, A0A6Q8PHP4
      Related
      ENSP00000501997.1, ENST00000675710.1
      Conserved Domains (4) summary
      smart00502
      Location:75 → 201
      BBC; B-Box C-terminal domain
      smart00557
      Location:239 → 335
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:385 → 658
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd19824
      Location:29 → 70
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    22. NM_001375523.1 → NP_001362452.1  tripartite motif-containing protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS93657.1
      UniProtKB/TrEMBL
      A0A6Q8PFB0, A0A6Q8PHP4
      Conserved Domains (4) summary
      smart00502
      Location:75 → 201
      BBC; B-Box C-terminal domain
      smart00557
      Location:239 → 335
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:385 → 658
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd19824
      Location:29 → 70
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    23. NM_001375525.1 → NP_001362454.1  tripartite motif-containing protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC013477, AC114791
      Consensus CDS
      CCDS93657.1
      UniProtKB/TrEMBL
      A0A6Q8PFB0, A0A6Q8PHP4
      Related
      ENSP00000502776.1, ENST00000675782.1
      Conserved Domains (4) summary
      smart00502
      Location:75 → 201
      BBC; B-Box C-terminal domain
      smart00557
      Location:239 → 335
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:385 → 658
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd19824
      Location:29 → 70
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    24. NM_015271.5 → NP_056086.2  tripartite motif-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_056086.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF220018, AL110178, BC011052, DA631098
      Consensus CDS
      CCDS3781.2
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000339659.5, ENST00000338700.10
      Conserved Domains (7) summary
      smart00502
      Location:188 → 314
      BBC; B-Box C-terminal domain
      smart00336
      Location:140 → 181
      BBOX; B-Box-type zinc finger
      smart00557
      Location:352 → 448
      IG_FLMN; Filamin-type immunoglobulin domains
      COG3391
      Location:562 → 762
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00162
      Location:50 → 93
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14960
      Location:498 → 771
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      pfam00630
      Location:352 → 445
      Filamin; Filamin/ABP280 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      153152163..153339317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531796.4 → XP_011530098.1  tripartite motif-containing protein 2 isoform X4

      See identical proteins and their annotated locations for XP_011530098.1

      UniProtKB/TrEMBL
      A0A6Q8PFX3, A0A6Q8PG16
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 748
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    2. XM_017007948.3 → XP_016863437.1  tripartite motif-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Related
      ENSP00000502519.1, ENST00000674874.1
      Conserved Domains (6) summary
      smart00502
      Location:161 → 287
      BBC; B-Box C-terminal domain
      smart00557
      Location:325 → 421
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5432
      Location:6 → 109
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16767
      Location:20 → 65
      RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
      cd19824
      Location:115 → 156
      Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

    3. XM_047449953.1 → XP_047305909.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    4. XM_006714157.2 → XP_006714220.1  tripartite motif-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PFX3
      Related
      ENST00000674718.1
      Conserved Domains (8) summary
      smart00502
      Location:188 → 314
      BBC; B-Box C-terminal domain
      smart00336
      Location:140 → 181
      BBOX; B-Box-type zinc finger
      smart00557
      Location:352 → 448
      IG_FLMN; Filamin-type immunoglobulin domains
      COG3391
      Location:562 → 766
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00162
      Location:50 → 93
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14960
      Location:498 → 775
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      pfam00630
      Location:352 → 445
      Filamin; Filamin/ABP280 repeat
      sd00039
      Location:519 → 554
      7WD40; WD40 repeat [structural motif]

    5. XM_006714158.2 → XP_006714221.1  tripartite motif-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A6Q8PFX3
      Related
      ENST00000675363.1
      Conserved Domains (8) summary
      smart00502
      Location:187 → 313
      BBC; B-Box C-terminal domain
      smart00336
      Location:139 → 180
      BBOX; B-Box-type zinc finger
      smart00557
      Location:351 → 447
      IG_FLMN; Filamin-type immunoglobulin domains
      COG3391
      Location:561 → 765
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00162
      Location:49 → 92
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14960
      Location:497 → 774
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      pfam00630
      Location:351 → 444
      Filamin; Filamin/ABP280 repeat
      sd00039
      Location:518 → 553
      7WD40; WD40 repeat [structural motif]

    6. XM_017007943.2 → XP_016863432.1  tripartite motif-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A6Q8PFB0
      Conserved Domains (7) summary
      smart00502
      Location:187 → 313
      BBC; B-Box C-terminal domain
      smart00336
      Location:139 → 180
      BBOX; B-Box-type zinc finger
      smart00557
      Location:351 → 447
      IG_FLMN; Filamin-type immunoglobulin domains
      COG3391
      Location:561 → 761
      YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
      cd00162
      Location:49 → 92
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14960
      Location:497 → 770
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      pfam00630
      Location:351 → 444
      Filamin; Filamin/ABP280 repeat

    7. XM_047449949.1 → XP_047305905.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16
      Related
      ENSP00000502775.1, ENST00000675899.1

    8. XM_047449952.1 → XP_047305908.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    9. XM_047449951.1 → XP_047305907.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    10. XM_047449954.1 → XP_047305910.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16
      Related
      ENSP00000502331.1, ENST00000676167.1

    11. XM_017007953.3 → XP_016863442.1  tripartite motif-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      C9J084
      Conserved Domains (4) summary
      smart00502
      Location:36 → 162
      BBC; B-Box C-terminal domain
      smart00557
      Location:200 → 296
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:346 → 623
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cl00034
      Location:1 → 31
      Bbox_SF; B-box-type zinc finger superfamily

    12. XM_006714165.4 → XP_006714228.1  tripartite motif-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006714228.1

      UniProtKB/TrEMBL
      C9J084
      Conserved Domains (4) summary
      smart00502
      Location:36 → 162
      BBC; B-Box C-terminal domain
      smart00557
      Location:200 → 296
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:346 → 623
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cl00034
      Location:1 → 31
      Bbox_SF; B-box-type zinc finger superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      156476134..156663746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349487.1 → XP_054205462.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    2. XM_054349489.1 → XP_054205464.1  tripartite motif-containing protein 2 isoform X5

      UniProtKB/Swiss-Prot
      D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1

    3. XM_054349488.1 → XP_054205463.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    4. XM_054349483.1 → XP_054205458.1  tripartite motif-containing protein 2 isoform X1

    5. XM_054349484.1 → XP_054205459.1  tripartite motif-containing protein 2 isoform X2

    6. XM_054349485.1 → XP_054205460.1  tripartite motif-containing protein 2 isoform X3

    7. XM_054349486.1 → XP_054205461.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    8. XM_054349491.1 → XP_054205466.1  tripartite motif-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PG16

    9. XM_054349490.1 → XP_054205465.1  tripartite motif-containing protein 2 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C040.1 GenPept UniProtKB/Swiss-Prot:Q9C040

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