ACSL5 acyl-CoA synthetase long chain family member 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ACSL5provided by HGNC
Official Full Name: acyl-CoA synthetase long chain family member 5provided by HGNC
Primary source: HGNC:HGNC:16526
See related: Ensembl:ENSG00000197142 MIM:605677; AllianceGenome:HGNC:16526
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACS2; ACS5; FACL5; DIAR13
Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q25.2

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (112374116..112428376)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (113265142..113319056)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (114133874..114188134)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/beta-catenin signaling by palmitoylation modification.
Title: ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification.
More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.
Title: More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.
Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.
Title: Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma.
Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.
Title: Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.
The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects.
Title: The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects.
Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
Title: Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism.
Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset.
Title: Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset.
ACYL-CoA synthetase long-chain 5 polymorphism is associated with weight loss and metabolic changes in response to a partial meal-replacement hypocaloric diet.", trans "El polimorfismo de la ACYL-CoA-sintetasa de cadena larga 5 se asocia a perdida de peso y cambios metabolicos en respuesta a una dieta hipocalorica parcial de reemplazo.
Title: ACYL-CoA synthetase long-chain 5 polymorphism is associated with weight loss and metabolic changes in response to a partial meal-replacement hypocaloric diet.
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
Title: A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.
Title: ONECUT2 upregulation is associated with CpG hypomethylation at promoter-proximal DNA in gastric cancer and triggers ACSL5.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Diarrhea 13 MedGen: C5830477 OMIM: 620357 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	Depletion of the ACSL5 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20863 (e-PCR)
- UniSTS:15928

A006J06 (e-PCR)
- UniSTS:15929

RH47726 (e-PCR)
- UniSTS:23097

D10S1429 (e-PCR), detects polymorphism
- UniSTS:49984

WI-12237 (e-PCR)
- UniSTS:61940

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables arachidonate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info
enables oleoyl-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty-acyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	TAS Traceable Author Statement more info
involved_in positive regulation of long-chain fatty acid import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: long-chain-fatty-acid--CoA ligase 5

Names: FACL5 for fatty acid coenzyme A ligase 5; LACS 5; arachidonate--CoA ligase; fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5

NP_001373966.1

EC 6.2.1.15

EC 6.2.1.3

NP_057318.2

EC 6.2.1.15

EC 6.2.1.3

NP_976313.1

EC 6.2.1.15

EC 6.2.1.3

NP_976314.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001387037.1 → NP_001373966.1 long-chain-fatty-acid--CoA ligase 5 isoform c

Status: REVIEWED

Source sequence(s)

AL157786

Consensus CDS

CCDS91344.1

UniProtKB/TrEMBL

A0A8C8KCK5, A0A8C8L3F5

Related

ENSP00000403647.2, ENST00000433418.6

Conserved Domains (1) summary

cd05927
Location:157 → 710

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
NM_016234.4 → NP_057318.2 long-chain-fatty-acid--CoA ligase 5 isoform a

See identical proteins and their annotated locations for NP_057318.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AK024932, AL708480, AY358520

Consensus CDS

CCDS7572.1

UniProtKB/TrEMBL

A0A8C8KCK5

Related

ENSP00000348429.1, ENST00000356116.6

Conserved Domains (2) summary

PLN02736
Location:127 → 737

PLN02736; long-chain acyl-CoA synthetase

cd05927
Location:157 → 734

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
NM_203379.2 → NP_976313.1 long-chain-fatty-acid--CoA ligase 5 isoform b

See identical proteins and their annotated locations for NP_976313.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (b) that has a shorter N-terminus compared to isoform a. Both variants 2 and 3 encode isoform b.

Source sequence(s)

AK000339, AK024932, AL157786, AY358520, CF595490

Consensus CDS

CCDS7573.1

UniProtKB/Swiss-Prot

A6GV77, D3DRB3, Q6UX44, Q9UIU4, Q9ULC5

UniProtKB/TrEMBL

A0A8C8KCK5

Related

ENSP00000346680.4, ENST00000354655.9

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
NM_203380.2 → NP_976314.1 long-chain-fatty-acid--CoA ligase 5 isoform b

See identical proteins and their annotated locations for NP_976314.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. This results in translation initiation from a downstream ATG and an isoform (b) that has a shorter N-terminus compared to isoform a. Both variants 2 and 3 encode isoform b.

Source sequence(s)

AK024932, AL708480, AY358520, CD689921

Consensus CDS

CCDS7573.1

UniProtKB/Swiss-Prot

A6GV77, D3DRB3, Q6UX44, Q9UIU4, Q9ULC5

UniProtKB/TrEMBL

A0A8C8KCK5

Related

ENSP00000376796.1, ENST00000393081.6

Conserved Domains (1) summary

cd05927
Location:101 → 678

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)