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    DICER1 dicer 1, ribonuclease III [ Homo sapiens (human) ]

    Gene ID: 23405, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DICER1provided by HGNC
    Official Full Name
    dicer 1, ribonuclease IIIprovided by HGNC
    Primary source
    HGNC:HGNC:17098
    See related
    Ensembl:ENSG00000100697 MIM:606241; AllianceGenome:HGNC:17098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
    Summary
    This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in appendix (RPKM 6.6), placenta (RPKM 6.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DICER1 in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95086228..95158010, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89316445..89388228, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95552565..95624347, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984646 Neighboring gene long intergenic non-protein coding RNA 2279 Neighboring gene NANOG hESC enhancer GRCh37_chr14:95446338-95446918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95469279-95469780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95511279-95511812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95511813-95512347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95522504-95523004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8948 Neighboring gene microRNA 3173 Neighboring gene DICER1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:95662653-95662819 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95665195-95666123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8949 Neighboring gene calmin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95719574-95720500 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95720501-95721426 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95721427-95722352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95725084-95725755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95725756-95726426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95727628-95728254 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:95731514-95732713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95769323-95769824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6045 Neighboring gene uncharacterized LOC105370637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. Gazon H, et al. Oncotarget, 2016 May 24. PMID 26849145, Free PMC Article
    2. The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. Wang Y, et al. Neoplasia, 2015 Aug. PMID 26408257, Free PMC Article
    3. A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors. Conlon N, et al. Mod Pathol, 2015 Dec. PMID 26428316, Free PMC Article
    4. Mixed Epithelial and Stromal Tumor of the Kidney: Mutation Analysis of the DICER 1 Gene in 29 Cases. Vanecek T, et al. Appl Immunohistochem Mol Morphol, 2017 Feb. PMID 26509905
    5. DICER1 deletion and 14q32 microdeletion syndrome: an additional case and a review of the literature. Ting TW, et al. Clin Dysmorphol, 2016 Jan. PMID 26513514

    See all (646) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DICER1 Variants in Pediatric and Young Adult Thyroid Nodules.
      Title: DICER1 Variants in Pediatric and Young Adult Thyroid Nodules.
    2. Understanding the Dosage-Dependent Role of Dicer1 in Thyroid Tumorigenesis.
      Title: Understanding the Dosage-Dependent Role of Dicer1 in Thyroid Tumorigenesis.
    3. DICER1-sarcomas of GYN tract: Expanding on an emerging entity.
      Title: DICER1-sarcomas of GYN tract: Expanding on an emerging entity.
    4. Cryo-EM structures of human DICER dicing a pre-miRNA substrate.
      Title: Cryo-EM structures of human DICER dicing a pre-miRNA substrate.
    5. Sertoli-Leydig tumor and DICER1 gene mutation: A case series and literature review.
      Title: Sertoli-Leydig tumor and DICER1 gene mutation: A case series and literature review.
    6. Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.
      Title: Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.
    7. [The clinicopathological features of adult thyroid tumors with DICER1 mutation].
      Title: [The clinicopathological features of adult thyroid tumors with DICER1 mutation].
    8. Prevalence of lung cysts in adolescents and adults with a germline DICER1 pathogenic/likely pathogenic variant: a report from the National Institutes of Health and International Pleuropulmonary Blastoma/DICER1 Registry.
      Title: Prevalence of lung cysts in adolescents and adults with a germline DICER1 pathogenic/likely pathogenic variant: a report from the National Institutes of Health and International Pleuropulmonary Blastoma/DICER1 Registry.
    9. Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1-altered thyroid lesions on FNA: A multipractice experience.
      Title: Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1-altered thyroid lesions on FNA: A multipractice experience.
    10. Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.
      Title: Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.
    Submit: New GeneRIF Correction See all GeneRIFs (490)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Euthyroid goiter
    MedGen: C0302859 OMIM: 138800 GeneReviews: DICER1 Tumor Predisposition
    		not available
    Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
    MedGen: C4748924 OMIM: 618272 GeneReviews: Not available
    		not available
    Pleuropulmonary blastoma
    MedGen: C1266144 OMIM: 601200 GeneReviews: DICER1 Tumor Predisposition
    		not available
    Rhabdomyosarcoma, embryonal, 2
    MedGen: C1867234 OMIM: 180295 GeneReviews: DICER1 Tumor Predisposition
    		not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-09)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2022-02-09)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Knockdown of Dicer by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed
    gag Interaction of HIV-1 Gag with dicer 1, ribonuclease type III (DICER1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process PubMed
    Tat tat The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process PubMed
    tat HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction PubMed
    Vpr vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
    vpr HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0928

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA endonuclease activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonuclease III activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease III activity TAS
    Traceable Author Statement
    more info
    		  
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RISC complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in global gene silencing by mRNA cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in miRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of Schwann cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peripheral nervous system myelin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Schwann cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing TAS
    Traceable Author Statement
    more info
    		  
    involved_in tRNA decay TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    NOT part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RISC-loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RISC-loading complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RISC-loading complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    dicer 1, double-stranded RNA-specific endoribonuclease
    dicer 1, ribonuclease type III
    helicase MOI
    helicase with RNAse motif
    NP_001182502.1
    NP_001258211.1
    NP_001278557.1
    NP_001382606.1
    NP_001382607.1
    NP_001382608.1
    NP_001382609.1
    NP_001382611.1
    NP_001382612.1
    NP_001382613.1
    NP_001382615.1
    NP_001382616.1
    NP_001382617.1
    NP_001382618.1
    NP_001382619.1
    NP_001382620.1
    NP_001382621.1
    NP_001382622.1
    NP_001382623.1
    NP_001382624.1
    NP_001382625.1
    NP_001382626.1
    NP_001382627.1
    NP_001382628.1
    NP_001382629.1
    NP_085124.2
    NP_803187.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016311.1 RefSeqGene

      Range
      4413..76195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

    mRNA and Protein(s)

    1. NM_001195573.1 → NP_001182502.1  endoribonuclease Dicer isoform 2

      See identical proteins and their annotated locations for NP_001182502.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL356017, AL390254, HM595745
      Consensus CDS
      CCDS55941.1
      UniProtKB/TrEMBL
      A0A8Q3SJI0, A0A8Q3WLJ5
      Related
      ENSP00000444719.1, ENST00000541352.5
      Conserved Domains (10) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      smart00487
      Location:40 → 242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445 → 589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:1666 → 1765
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58 → 209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:1682 → 1767
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445 → 553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631 → 714
      Dicer_dimer; Dicer dimerization domain

    2. NM_001271282.3 → NP_001258211.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_001258211.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000435681.1, ENST00000527414.5
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    3. NM_001291628.2 → NP_001278557.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_001278557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254, AY845868, BM152875
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    4. NM_001395677.1 → NP_001382606.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    5. NM_001395678.1 → NP_001382607.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    6. NM_001395679.1 → NP_001382608.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000376783.1, ENST00000393063.6
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    7. NM_001395680.1 → NP_001382609.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    8. NM_001395682.1 → NP_001382611.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000502730.2, ENST00000674628.2
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    9. NM_001395683.1 → NP_001382612.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    10. NM_001395684.1 → NP_001382613.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    11. NM_001395686.1 → NP_001382615.1  endoribonuclease Dicer isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (6) summary
      smart00535
      Location:1202 → 1293
      RIBOc; Ribonuclease III family
      COG0571
      Location:1572 → 1824
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:792 → 914
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:177 → 271
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:278 → 470
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:11 → 145
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    12. NM_001395687.1 → NP_001382616.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1161 → 1252
      RIBOc; Ribonuclease III family
      COG0571
      Location:1531 → 1783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751 → 873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136 → 230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237 → 429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495 → 583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12 → 104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    13. NM_001395688.1 → NP_001382617.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1161 → 1252
      RIBOc; Ribonuclease III family
      COG0571
      Location:1531 → 1783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751 → 873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136 → 230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237 → 429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495 → 583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12 → 104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    14. NM_001395689.1 → NP_001382618.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENST00000696921.1
      Conserved Domains (7) summary
      smart00535
      Location:1161 → 1252
      RIBOc; Ribonuclease III family
      COG0571
      Location:1531 → 1783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751 → 873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136 → 230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237 → 429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495 → 583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12 → 104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    15. NM_001395690.1 → NP_001382619.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:1161 → 1252
      RIBOc; Ribonuclease III family
      COG0571
      Location:1531 → 1783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751 → 873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136 → 230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237 → 429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495 → 583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12 → 104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    16. NM_001395691.1 → NP_001382620.1  endoribonuclease Dicer isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (6) summary
      smart00535
      Location:1107 → 1198
      RIBOc; Ribonuclease III family
      COG0571
      Location:1477 → 1729
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:697 → 819
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:82 → 176
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:183 → 375
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:1 → 50
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    17. NM_001395692.1 → NP_001382621.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Related
      ENSP00000452556.2, ENST00000532939.3
      Conserved Domains (6) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:1669 → 1708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    18. NM_001395693.1 → NP_001382622.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Related
      ENSP00000512841.1, ENST00000696737.1
      Conserved Domains (6) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:1669 → 1708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    19. NM_001395694.1 → NP_001382623.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Conserved Domains (6) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:1669 → 1708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    20. NM_001395695.1 → NP_001382624.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Conserved Domains (6) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:1669 → 1708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

    21. NM_001395696.1 → NP_001382625.1  endoribonuclease Dicer isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLJ5
      Conserved Domains (6) summary
      smart00535
      Location:1161 → 1252
      RIBOc; Ribonuclease III family
      cd02843
      Location:751 → 873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:1534 → 1573
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:136 → 230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237 → 429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:12 → 104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    22. NM_001395697.1 → NP_001382626.1  endoribonuclease Dicer isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Conserved Domains (3) summary
      smart00535
      Location:735 → 826
      RIBOc; Ribonuclease III family
      COG0571
      Location:1105 → 1357
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:325 → 447
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

    23. NM_001395698.1 → NP_001382627.1  endoribonuclease Dicer isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL356017
      Conserved Domains (3) summary
      cd15903
      Location:136 → 230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237 → 429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:12 → 104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    24. NM_001395699.1 → NP_001382628.1  endoribonuclease Dicer isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL356017
      UniProtKB/TrEMBL
      A0A6Q8PH99
      Related
      ENSP00000502591.1, ENST00000675995.1
      Conserved Domains (3) summary
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      cl38915
      Location:372 → 458
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases

    25. NM_001395700.1 → NP_001382629.1  endoribonuclease Dicer isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL356017
      UniProtKB/TrEMBL
      A0A6Q8PH99
      Conserved Domains (3) summary
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      cl38915
      Location:372 → 459
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases

    26. NM_030621.4 → NP_085124.2  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_085124.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254, AY845867, BM152875
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000437256.1, ENST00000526495.6
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    27. NM_177438.3 → NP_803187.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_803187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AB023145, AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000343745.3, ENST00000343455.8
      Conserved Domains (7) summary
      smart00535
      Location:1296 → 1387
      RIBOc; Ribonuclease III family
      COG0571
      Location:1666 → 1918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:886 → 1008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372 → 564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42 → 239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630 → 718
      Dicer_dimer; Dicer dimerization domain

    RNA

    1. NR_172715.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254

    2. NR_172716.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254

    3. NR_172717.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254

    4. NR_172718.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Related
      ENST00000675540.2

    5. NR_172719.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254

    6. NR_172720.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      95086228..95158010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      89316445..89388228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001395685.1: Suppressed sequence

      Description
      NM_001395685.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPY3.3 GenPept UniProtKB/Swiss-Prot:Q9UPY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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