Washc2 WASH complex subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Washc2provided by MGI
Official Full Name: WASH complex subunit 2provided by MGI
Primary source: MGI:MGI:106463
See related: Ensembl:ENSMUSG00000024104 AllianceGenome:MGI:106463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam21; D6Wsu116e; A130095H06; C530005J20Rik
Summary: Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in protein localization to endosome and retrograde transport, endosome to Golgi. Part of WASH complex. Is expressed in several structures, including extraembryonic component; liver; and neural retina. Orthologous to several human genes including WASHC2A (WASH complex subunit 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 42.3), CNS E11.5 (RPKM 17.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 53.76 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (116184988..116239632)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (116208019..116262672)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.
Title: FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Wsu116e (e-PCR), detects polymorphism
- UniSTS:142646

RH124879 (e-PCR)
- UniSTS:161701

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosomal transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to endosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	NAS Non-traceable Author Statement more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IDA Inferred from Direct Assay more info	PubMed
part_of WASH complex	ISO Inferred from Sequence Orthology more info
part_of WASH complex	ISS Inferred from Sequence or Structural Similarity more info
part_of WASH complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	NAS Non-traceable Author Statement more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WASH complex subunit 2

Names: WASH complex subunit 2`; WASH complex subunit FAM21; family with sequence similarity 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026585.3 → NP_080861.2 WASH complex subunit 2

See identical proteins and their annotated locations for NP_080861.2

Status: VALIDATED

Source sequence(s)

AK038318, AK145716, BY768668, W45964

Consensus CDS

CCDS20450.1

UniProtKB/Swiss-Prot

Q3TQ99, Q6PGL7, Q80TW8, Q80UQ4, Q8CAP0

Related

ENSMUSP00000038983.9, ENSMUST00000036759.11

Conserved Domains (1) summary

pfam15255
Location:944 → 1071

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

116184988..116239632

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506214.4 → XP_006506277.1 WASH complex subunit 2 isoform X1

Conserved Domains (1) summary

pfam15255
Location:920 → 1054

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_030255438.2 → XP_030111298.1 WASH complex subunit 2 isoform X2

Conserved Domains (1) summary

pfam15255
Location:891 → 983

CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
XM_036166202.1 → XP_036022095.1 WASH complex subunit 2 isoform X3

UniProtKB/TrEMBL

A0A0N4SV74

Related

ENSMUSP00000144982.2, ENSMUST00000204476.3