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    Ube2i ubiquitin-conjugating enzyme E2I [ Mus musculus (house mouse) ]

    Gene ID: 22196, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ube2iprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by MGI
    Primary source
    MGI:MGI:107365
    See related
    Ensembl:ENSMUSG00000015120 AllianceGenome:MGI:107365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC9; Ubce9; Ubce2i; 5830467E05Rik
    Summary
    Enables HLH domain binding activity and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nuclear export; and protein sumoylation. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction. Located in nuclear body. Part of SUMO ligase complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 68.8), whole brain E14.5 (RPKM 68.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2i in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25479484..25494965, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25260510..25275799, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34 Neighboring gene predicted gene, 25921

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables HLH domain binding PubMed 
    enables RING-like zinc finger domain binding  
    enables SUMO conjugating enzyme activity  
    enables SUMO conjugating enzyme activity PubMed 
    enables SUMO conjugating enzyme activity  
    enables SUMO transferase activity  
    enables bHLH transcription factor binding  
    enables enzyme binding  
    enables ionotropic glutamate receptor binding  
    enables protein binding PubMed 
    enables small protein activating enzyme binding  
    enables transcription coregulator binding  
    enables transcription factor binding  
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in chromosome segregation  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nuclear export PubMed 
    involved_in nuclear export  
    involved_in positive regulation of SUMO transferase activity  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cell migration  
    involved_in protein modification process PubMed 
    involved_in protein sumoylation  
    involved_in protein sumoylation PubMed 
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in PML body  
    part_of SUMO ligase complex PubMed 
    part_of SUMO ligase complex  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in dendrite  
    located_in fibrillar center  
    is_active_in glutamatergic synapse PubMed 
    located_in nuclear body PubMed 
    located_in nuclear body  
    located_in nuclear envelope  
    part_of nuclear pore PubMed 
    is_active_in nucleoplasm PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in postsynaptic cytosol PubMed 
    is_active_in presynaptic cytosol PubMed 
    part_of transferase complex  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    RING-type E3 SUMO transferase UBC9
    SUMO-protein ligase
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-protein ligase I
    NP_001171080.1
    NP_001171081.1
    NP_001344623.1
    NP_035795.1
    XP_006524112.1
    XP_036016378.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177609.1NP_001171080.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK150575, AK166657, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      UniProtKB/TrEMBL
      A0AAA9WWE2
      Related
      ENSMUSP00000134261.2, ENSMUST00000173084.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001177610.1NP_001171081.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC122454, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      UniProtKB/TrEMBL
      A0AAA9WWE2
      Related
      ENSMUSP00000134350.2, ENSMUST00000174031.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_001357694.1NP_001344623.1  SUMO-conjugating enzyme UBC9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC122454, CD776278
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      UniProtKB/TrEMBL
      A0AAA9WWE2
      Related
      ENSMUSP00000134161.3, ENSMUST00000173621.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    4. NM_011665.4NP_035795.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_035795.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK005058, BY074880
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      UniProtKB/TrEMBL
      A0AAA9WWE2
      Related
      ENSMUSP00000134491.2, ENSMUST00000173713.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25479484..25494965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524049.5XP_006524112.1  SUMO-conjugating enzyme UBC9 isoform X1

      See identical proteins and their annotated locations for XP_006524112.1

      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      UniProtKB/TrEMBL
      A0AAA9WWE2
      Related
      ENSMUSP00000055714.10, ENSMUST00000049911.17
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_036160485.1XP_036016378.1  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/Swiss-Prot
      P63280, Q6RUT3
      UniProtKB/TrEMBL
      A0AAA9WWE2
      Related
      ENSMUSP00000159860.1, ENSMUST00000249684.1
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
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