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    Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha [ Mus musculus (house mouse) ]

    Gene ID: 51792, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ppp2r1aprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit A, alphaprovided by MGI
    Primary source
    MGI:MGI:1926334
    See related
    Ensembl:ENSMUSG00000007564 AllianceGenome:MGI:1926334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP2A; PR65; 6330556D22Rik
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in T cell homeostasis and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol. Part of protein phosphatase type 2A complex. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 147.1), CNS E18 (RPKM 140.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ppp2r1a in Genome Data Viewer
    Location:
    17 A3.2; 17 11.4 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21165716..21186167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (20945454..20965905)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 232 Neighboring gene vomeronasal 1 receptor, pseudogene 144 Neighboring gene STARR-positive B cell enhancer ABC_E264 Neighboring gene vomeronasal 1 receptor, pseudogene 145 Neighboring gene STARR-seq mESC enhancer starr_42003 Neighboring gene vomeronasal 1 receptor 233

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein antigen binding  
    enables protein antigen binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein phosphatase regulator activity  
    enables protein serine/threonine phosphatase activity PubMed 
    Process Evidence Code Pubs
    involved_in T cell homeostasis PubMed 
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    acts_upstream_of_or_within female meiotic nuclear division PubMed 
    involved_in meiotic sister chromatid cohesion, centromeric  
    acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric PubMed 
    acts_upstream_of_or_within meiotic spindle elongation PubMed 
    acts_upstream_of_or_within mitotic sister chromatid separation PubMed 
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within peptidyl-serine dephosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    acts_upstream_of_or_within regulation of meiotic cell cycle process involved in oocyte maturation PubMed 
    involved_in spindle assembly  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex  
    part_of FAR/SIN/STRIPAK complex  
    located_in chromosome, centromeric region  
    located_in chromosome, centromeric region  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in dendrite  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in neuronal cell body  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of protein phosphatase type 2A complex  
    part_of protein phosphatase type 2A complex PubMed 
    part_of protein phosphatase type 2A complex  
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Names
    protein phosphatase PP2A
    serine/threonine protein phosphatase A subunit type 2A
    NP_058587.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016891.3NP_058587.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

      See identical proteins and their annotated locations for NP_058587.1

      Status: PROVISIONAL

      Source sequence(s)
      AC109204
      Consensus CDS
      CCDS28432.1
      UniProtKB/Swiss-Prot
      Q76MZ3
      Related
      ENSMUSP00000007708.8, ENSMUST00000007708.14
      Conserved Domains (3) summary
      COG1413
      Location:187462
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:245269
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:166196
      HEAT; HEAT repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      21165716..21186167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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