Eml1 EMAP like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eml1provided by RGD
Official Full Name: EMAP like 1provided by RGD
Primary source: RGD:1306374
See related: EnsemblRapid:ENSRNOG00000043143 AllianceGenome:RGD:1306374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in brain development; mitotic spindle organization; and neuroblast proliferation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to colocalize with mitotic spindle. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 234.9), Heart (RPKM 166.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (133048271..133221642)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (127283968..127457246)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (132367342..132450488)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eml1 promotes axonal growth by enhancing alphaTAT1-mediated microtubule acetylation.
Title: Eml1 promotes axonal growth by enhancing αTAT1-mediated microtubule acetylation.
A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat.
Title: A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF409188 (e-PCR)
- UniSTS:248951

BM390550 (e-PCR)
- UniSTS:260787

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 1

Names: EMAP-1; echinoderm microtubule associated protein like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025741.2 → NP_001020912.1 echinoderm microtubule-associated protein-like 1 isoform 5

See identical proteins and their annotated locations for NP_001020912.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6ASI8

Related

ENSRNOP00000067418.4, ENSRNOT00000071733.4

Conserved Domains (4) summary

COG2319
Location:371 → 782

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:153 → 226

HELP; HELP motif

sd00039
Location:342 → 384

7WD40; WD40 repeat [structural motif]

cl02567
Location:233 → 621

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001399709.1 → NP_001386638.1 echinoderm microtubule-associated protein-like 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6AVR0

Related

ENSRNOP00000096898.1, ENSRNOT00000118546.2
NM_001399710.1 → NP_001386639.1 echinoderm microtubule-associated protein-like 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

Related

ENSRNOP00000097362.2, ENSRNOT00000108825.2
NM_001399711.1 → NP_001386640.1 echinoderm microtubule-associated protein-like 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q4V8C3

Related

ENSRNOP00000090244.2, ENSRNOT00000114172.2
NM_001399712.1 → NP_001386641.1 echinoderm microtubule-associated protein-like 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

RNA

NR_174190.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NR_174191.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

133048271..133221642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112547.2 → XP_038968475.1 echinoderm microtubule-associated protein-like 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A157, A0A8I6ASI8

Related

ENSRNOP00000085896.1, ENSRNOT00000107380.2

Conserved Domains (4) summary

sd00039
Location:377 → 419

7WD40; WD40 repeat [structural motif]

pfam03451
Location:188 → 261

HELP; HELP motif

cl29593
Location:268 → 656

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl41737
Location:19 → 66

TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
XM_039112551.2 → XP_038968479.1 echinoderm microtubule-associated protein-like 1 isoform X3

UniProtKB/TrEMBL

A0A8I6ASI8

Conserved Domains (4) summary

sd00039
Location:359 → 401

7WD40; WD40 repeat [structural motif]

pfam03451
Location:170 → 243

HELP; HELP motif

cl29593
Location:250 → 638

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl41737
Location:1 → 48

TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
XM_063262135.1 → XP_063118205.1 echinoderm microtubule-associated protein-like 1 isoform X4
XM_039112546.2 → XP_038968474.1 echinoderm microtubule-associated protein-like 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AD94, A0A8I6ASI8

Conserved Domains (4) summary

sd00039
Location:390 → 432

7WD40; WD40 repeat [structural motif]

pfam03451
Location:201 → 274

HELP; HELP motif

cd21947
Location:22 → 79

TD_EMAP1; trimerization domain of echinoderm microtubule-associated protein-like 1

cl29593
Location:281 → 669

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112550.2 → XP_038968478.1 echinoderm microtubule-associated protein-like 1 isoform X3

UniProtKB/TrEMBL

A0A8I6ASI8

Conserved Domains (4) summary

sd00039
Location:359 → 401

7WD40; WD40 repeat [structural motif]

pfam03451
Location:170 → 243

HELP; HELP motif

cl29593
Location:250 → 638

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl41737
Location:1 → 48

TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
XM_039112552.2 → XP_038968480.1 echinoderm microtubule-associated protein-like 1 isoform X5

UniProtKB/TrEMBL

A6KBG3

Conserved Domains (3) summary

sd00039
Location:251 → 293

7WD40; WD40 repeat [structural motif]

pfam03451
Location:62 → 135

HELP; HELP motif

cl29593
Location:142 → 530

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039112553.2 → XP_038968481.1 echinoderm microtubule-associated protein-like 1 isoform X6

UniProtKB/TrEMBL

A6KBG3

Conserved Domains (3) summary

sd00039
Location:234 → 276

7WD40; WD40 repeat [structural motif]

pfam03451
Location:45 → 118

HELP; HELP motif

cl29593
Location:125 → 513

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...