Rwdd3 RWD domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rwdd3provided by RGD
Official Full Name: RWD domain containing 3provided by RGD
Primary source: RGD:620472
See related: EnsemblRapid:ENSRNOG00000029893 AllianceGenome:RGD:620472
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rsume; X2cr1
Summary: Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of protein sumoylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human RWDD3 (RWD domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 38.0), Lung (RPKM 36.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (211918361..211933644, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (209233622..209254842, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (224710351..224723136, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH137944 (e-PCR)
- UniSTS:220031

AI662458 (e-PCR)
- UniSTS:164224

RH137523 (e-PCR)
- UniSTS:219611

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RWD domain-containing protein 3

Names: RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; pituitary tumor X2CR1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128152.1 → NP_001121624.1 RWD domain-containing protein 3

See identical proteins and their annotated locations for NP_001121624.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P0C7N0

UniProtKB/TrEMBL

A0A8L2QK58, A6HVD1

Related

ENSRNOP00000039966.5, ENSRNOT00000040080.6

Conserved Domains (2) summary

pfam05773
Location:3 → 111

RWD; RWD domain

pfam06544
Location:146 → 258

DUF1115; Protein of unknown function (DUF1115)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

211918361..211933644 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103082.2 → XP_038959010.1 RWD domain-containing protein 3 isoform X1

Conserved Domains (1) summary

pfam05773
Location:3 → 111

RWD; RWD domain
XM_039103084.2 → XP_038959012.1 RWD domain-containing protein 3 isoform X2

Conserved Domains (1) summary

pfam06544
Location:48 → 160

DUF1115; Protein of unknown function (DUF1115)
XM_063282502.1 → XP_063138572.1 RWD domain-containing protein 3 isoform X3