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    Arid3a AT-rich interaction domain 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314616, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arid3aprovided by RGD
    Official Full Name
    AT-rich interaction domain 3Aprovided by RGD
    Primary source
    RGD:1305299
    See related
    EnsemblRapid:ENSRNOG00000026435 AllianceGenome:RGD:1305299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ARID3A (AT-rich interaction domain 3A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 36.6), Kidney (RPKM 35.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arid3a in Genome Data Viewer
    Location:
    7q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10403161..10431551, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9755291..9781260, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12573604..12602407, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 259 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B Neighboring gene WD repeat domain 18 Neighboring gene KISS1 receptor Neighboring gene R3H domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation. Nixon JC, et al. J Biol Chem, 2004 Dec 10. PMID 15456761
    2. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription. Tidwell JA, et al. Mol Immunol, 2011 Oct. PMID 21955986, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC189073

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AT-rich interactive domain-containing protein 3A
    Names
    AT rich interactive domain 3A (Bright like)
    dead ringer homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108066.2 → NP_001101536.2  AT-rich interactive domain-containing protein 3A

      See identical proteins and their annotated locations for NP_001101536.2

      Status: PROVISIONAL

      Source sequence(s)
      BC168846
      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Related
      ENSRNOP00000026708.6, ENSRNOT00000026708.9
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10403161..10431551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240905.5 → XP_006240967.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006240967.1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    2. XM_017594812.3 → XP_017450301.1  AT-rich interactive domain-containing protein 3A isoform X1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    3. XM_006240904.5 → XP_006240966.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006240966.1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    4. XM_008765169.4 → XP_008763391.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_008763391.1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    5. XM_039078974.2 → XP_038934902.1  AT-rich interactive domain-containing protein 3A isoform X1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    6. XM_039078976.2 → XP_038934904.1  AT-rich interactive domain-containing protein 3A isoform X1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    7. XM_006240902.5 → XP_006240964.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006240964.1

      UniProtKB/TrEMBL
      B5DEX9, E9PTY2
      Conserved Domains (1) summary
      cd16878
      Location:217 → 349
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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