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    Nudt8 nudix hydrolase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361692, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Nudt8provided by RGD
    Official Full Name
    nudix hydrolase 8provided by RGD
    Primary source
    RGD:1309040
    See related
    EnsemblRapid:ENSRNOG00000083053 AllianceGenome:RGD:1309040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable coenzyme A diphosphatase activity; magnesium ion binding activity; and manganese ion binding activity. Predicted to be involved in nucleoside phosphate catabolic process. Predicted to be located in mitochondrion. Orthologous to human NUDT8 (nudix hydrolase 8). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 852.2), Muscle (RPKM 226.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudt8 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210723209..210724717)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201293660..201295233)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219247428..219249155)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene aminoacylase 3 Neighboring gene T-box transcription factor 10 Neighboring gene double C2-like domains, gamma Neighboring gene uncharacterized LOC134483955 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coenzyme A diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coenzyme A diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in butyryl-CoA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in butyryl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in malonyl-CoA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malonyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in medium-chain fatty-acyl-CoA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in medium-chain fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in propionyl-CoA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial coenzyme A diphosphatase NUDT8
    Names
    nucleoside diphosphate-linked moiety X motif 8, mitochondrial
    nudix (nucleoside diphosphate linked moiety X)-type motif 8
    NP_001387779.1
    XP_008758411.1
    XP_063124199.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400850.1 → NP_001387779.1  mitochondrial coenzyme A diphosphatase NUDT8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYQ7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210723209..210724717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760189.4 → XP_008758411.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform X2

      UniProtKB/TrEMBL
      D3ZEH6
      Related
      ENSRNOP00000100071.1, ENSRNOT00000129621.1
      Conserved Domains (1) summary
      cd03426
      Location:31 → 201
      CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

    2. XM_063268129.1 → XP_063124199.1  mitochondrial coenzyme A diphosphatase NUDT8 isoform X1

      Related
      ENSRNOP00000108088.1, ENSRNOT00000163976.1
    Nucleotide Protein Strain
    Heading Accession and Version

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