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    Kctd1 potassium channel tetramerization domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291772, updated on 9-Dec-2024

    Summary

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    Symbol
    Kctd1provided by RGD
    Full Name
    potassium channel tetramerization domain containing 1provided by RGD
    Primary source
    RGD:621566
    See related
    EnsemblRapid:ENSRNOG00000016467 AllianceGenome:RGD:621566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vad; Vad5
    Summary
    Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in several cellular components, including centriolar satellite; intercellular bridge; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in scalp-ear-nipple syndrome. Orthologous to human KCTD1 (potassium channel tetramerization domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 104.1), Kidney (RPKM 62.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd1 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (6396947..6591026, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (6122390..6316434, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (6374778..6474990, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 4b Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134482908 Neighboring gene uncharacterized LOC134482909 Neighboring gene uncharacterized LOC134482910 Neighboring gene ribosomal protein L39, pseudogene 10 Neighboring gene uncharacterized LOC102551724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE). Li H, et al. Proc Natl Acad Sci U S A, 2004 Jan 13. PMID 14701905, Free PMC Article
    2. Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display. Luk JM, et al. Biochem Biophys Res Commun, 2003 Aug 8. PMID 12878178
    3. The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. Ding X, et al. J Cell Biochem, 2009 Feb 1. PMID 19115315
    4. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. Smaldone G, et al. FEBS Lett, 2016 Jun. PMID 27152988
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD1
    Names
    potassium channel tetramerisation domain containing 1
    vitamin A-deficient testicular protein 5
    vitamin A-deficient testicular protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100516.1 → NP_001093986.1  BTB/POZ domain-containing protein KCTD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6GJX3
      Related
      ENSRNOP00000109347.1, ENSRNOT00000171210.1
      Conserved Domains (3) summary
      smart00225
      Location:636 → 731
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl00213
      Location:279 → 434
      DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain
      cl02518
      Location:636 → 728
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      6396947..6591026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096741.2 → XP_038952669.1  BTB/POZ domain-containing protein KCTD1 isoform X2

      UniProtKB/TrEMBL
      A0A140TAI7
      Conserved Domains (2) summary
      cd18387
      Location:36 → 140
      BTB_POZ_KCTD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1)
      cl41727
      Location:162 → 245
      H1_KCTD12-like; H1 domain found in potassium channel tetramerization domain-containing proteins

    2. XM_039096743.2 → XP_038952671.1  BTB/POZ domain-containing protein KCTD1 isoform X3

      UniProtKB/Swiss-Prot
      Q8R4G8
      UniProtKB/TrEMBL
      A6KLU0
      Conserved Domains (2) summary
      cd18387
      Location:28 → 132
      BTB_POZ_KCTD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1)
      cl41727
      Location:154 → 237
      H1_KCTD12-like; H1 domain found in potassium channel tetramerization domain-containing proteins

    3. XM_039096742.2 → XP_038952670.1  BTB/POZ domain-containing protein KCTD1 isoform X3

      UniProtKB/Swiss-Prot
      Q8R4G8
      UniProtKB/TrEMBL
      A6KLU0
      Conserved Domains (2) summary
      cd18387
      Location:28 → 132
      BTB_POZ_KCTD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1)
      cl41727
      Location:154 → 237
      H1_KCTD12-like; H1 domain found in potassium channel tetramerization domain-containing proteins

    4. XM_063277266.1 → XP_063133336.1  BTB/POZ domain-containing protein KCTD1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4G8.2 GenPept UniProtKB/Swiss-Prot:Q8R4G8

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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