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    Keap1 Kelch-like ECH-associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117519, updated on 27-Dec-2024

    Summary

    Official Symbol
    Keap1provided by RGD
    Official Full Name
    Kelch-like ECH-associated protein 1provided by RGD
    Primary source
    RGD:621619
    See related
    EnsemblRapid:ENSRNOG00000020878 AllianceGenome:RGD:621619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Inrf2
    Summary
    Predicted to enable several functions, including disordered domain specific binding activity; transcription regulator inhibitor activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including response to immobilization stress; response to thyroid hormone; and selenium compound metabolic process. Located in adherens junction and focal adhesion. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 121.2), Adrenal (RPKM 108.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Keap1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28044555..28054042, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19768375..19777862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22250518..22259868, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene phosphodiesterase 4A Neighboring gene uncharacterized LOC134480144 Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to carbohydrate stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of epidermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to thyroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in selenium compound metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inclusion body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kelch-like ECH-associated protein 1
    Names
    cytosolic inhibitor of Nrf2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057152.2NP_476493.2  kelch-like ECH-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      G3V8U2
      Related
      ENSRNOP00000028360.3, ENSRNOT00000028360.6
      Conserved Domains (5) summary
      smart00612
      Location:467512
      Kelch; Kelch domain
      PHA03098
      Location:95595
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:456499
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67176
      BTB; BTB/POZ domain
      pfam07707
      Location:184282
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28044555..28054042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242591.5XP_006242653.1  kelch-like ECH-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006242653.1

      UniProtKB/TrEMBL
      A0A8I5ZVM9, A6JNQ1
      Conserved Domains (3) summary
      PHA03098
      Location:95599
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460503
      Kelch; KELCH repeat [structural motif]
      cd18248
      Location:56180
      BTB_POZ_KLHL19_KEAP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1)
    2. XM_039080715.2XP_038936643.1  kelch-like ECH-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVM9, A6JNQ1
      Conserved Domains (3) summary
      PHA03098
      Location:95599
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460503
      Kelch; KELCH repeat [structural motif]
      cd18248
      Location:56180
      BTB_POZ_KLHL19_KEAP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1)