Cpb2 carboxypeptidase B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpb2provided by RGD
Official Full Name: carboxypeptidase B2provided by RGD
Primary source: RGD:71035
See related: EnsemblRapid:ENSRNOG00000010935 AllianceGenome:RGD:71035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2523.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (56967128..57015964)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (50557722..50606569)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (57290849..57339762)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion.
Title: Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion.
Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension.
Title: Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target.
Thrombin-activatable fibrinolysis inhibitor is activated in an instant blood-mediated inflammatory reaction after intraportal islet transplant.
Title: Thrombin-activatable fibrinolysis inhibitor is activated in an instant blood-mediated inflammatory reaction after intraportal islet transplant.
Carboxypeptidase B2 and complement C3 were more abundant in the cerebrospinal fluid of experimental autoimmune encephalomyelitis rats that did not respond to minocyline treatment.
Title: Minocycline effects on the cerebrospinal fluid proteome of experimental autoimmune encephalomyelitis rats.
TAFI regulates plasmin activity through its enzymatic activity whereby it reduces the plasminogen-binding capacity of the hepatocytes; gene expression is down-regulated in hepatocyte proliferation for producing a fibrinolytic environment for cell growth
Title: A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture.
the region comprising alpha-helix 9 and beta-sheet 11 contributes to both human and rat TAFIa stability
Title: Conformational (in)stability of rat vs. human activated thrombin activatable fibrinolysis inhibitor.
Arterial, platelet-rich thrombi in vivo are degraded by naturally generated plasminogen activators. TAFI may play a significant role in the control of these mechanisms.
Title: Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles.
an increase in circulating TAFIa impairs endogenous clot lysis in a rat model of fibrin deposition
Title: Activated thrombin-activatable fibrinolysis inhibitor attenuates spontaneous fibrinolysis of batroxobin-induced fibrin deposition in rat lungs.

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General gene information

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Markers

Cpb2 (e-PCR), detects polymorphism
- UniSTS:506811

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibrinolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibrinolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of fibrinolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of plasminogen activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extracellular matrix constituent secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carboxypeptidase B2

Names: CPR; CPU; TAFI; carboxypeptidase B2 (plasma); carboxypeptidase R; carboxypeptidase U; thrombin-activable fibrinolysis inhibitor

NP_446069.1

EC 3.4.17.20

XP_038948873.1

EC 3.4.17.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053617.2 → NP_446069.1 carboxypeptidase B2 precursor

See identical proteins and their annotated locations for NP_446069.1

Status: VALIDATED

Source sequence(s)

BC107447, DY312674

UniProtKB/Swiss-Prot

Q3B7V3, Q5BKB8, Q9EQV9

UniProtKB/TrEMBL

A6HTS6

Related

ENSRNOP00000014909.4, ENSRNOT00000014909.9

Conserved Domains (2) summary

cd06246
Location:118 → 419

M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup

pfam02244
Location:32 → 103

Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

56967128..57015964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092945.2 → XP_038948873.1 carboxypeptidase B2 isoform X1

Conserved Domains (1) summary

cd06246
Location:25 → 326

M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup