Pcp4 Purkinje cell protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pcp4provided by RGD
Full Name: Purkinje cell protein 4provided by RGD
Primary source: RGD:3271
See related: EnsemblRapid:ENSRNOG00000001628 AllianceGenome:RGD:3271
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PEPZ19; pep-19
Summary: The protein encoded by this gene regulates H1˚ and H3.3 histone synthesis by binding to H1˚ and H3.3 histone mRNAs. The encoded protein can bind calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Expression: Biased expression in Brain (RPKM 1784.7) and Uterus (RPKM 207.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (49229185..49331186)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (35759711..35861725)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (36851035..36912272)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of PEP-19 suppresses angiotensin II-induced cardiomyocyte hypertrophy.
Title: Overexpression of PEP-19 suppresses angiotensin II-induced cardiomyocyte hypertrophy.
These findings suggest that PEP 19-ir neurons in the MDH may have a function in modulation of nociceptive and thermo-receptive signaling.
Title: Peptide 19-containing neurons in the medullary dorsal horn, subnuclei interpolaris and oralis, and nucleus principalis of the rat.
PCP4 promotes neuroendocrine cell differentiation and neurotransmitter release by activating calmodulin function.
Title: Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release.
PEP-19 and LPI bind H1 histone mRNA and that this binding is affected by calmodulin.
Title: RNA-binding activity of the rat calmodulin-binding PEP-19 protein and of the long PEP-19 isoform.
PEP-19 degradation by calpain might produce an aberrant activation of calmodulin functions, which in turn causes neuronal cell death
Title: Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload.
Pcp4 osteoplastic differentiation of bone marrow mesenchymal stem cells is mediated in part via Pcp4-induced calcium deposition to form mineral nodules.
Title: Expression of Pcp4 gene during osteogenic differentiation of bone marrow mesenchymal stem cells in vitro.
The novel rat-specific protein, tentatively named long PEP19 isoform (LPI), is the product of alternative splicing of the rat PCP4 gene encoding PEP19.
Title: Cloning of a rat-specific long PCP4/PEP19 isoform.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of CAMKK-AMPK signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CAMKK-AMPK signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in neurofilament	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calmodulin regulator protein PCP4

Names: Neuron specific protein PEP-19 (Purkinje cell protein 4); brain-specific antigen PCP-4; brain-specific polypeptide PEP-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270538.2 → NP_001257467.1 calmodulin regulator protein PCP4 isoform LPI

See identical proteins and their annotated locations for NP_001257467.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, which causes a frameshift and use of a different start codon compared to variant 1. The resulting isoform (LPI) has a longer and distinct N-terminus compared to isoform PEP19. Experimental support for this transcript and isoform is provided in PMID:22020791 and PMID:17273800.

Source sequence(s)

CB613293, JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6A0K8, F7F9D7, Q8CHN7

Related

ENSRNOP00000002221.5, ENSRNOT00000002221.8
NM_013002.4 → NP_037134.1 calmodulin regulator protein PCP4 isoform PEP19

See identical proteins and their annotated locations for NP_037134.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the smaller isoform (PEP19).

Source sequence(s)

CB613293, JAXUCZ010000011

UniProtKB/Swiss-Prot

P63055

UniProtKB/TrEMBL

A0A8I5ZX37

Related

ENSRNOP00000057764.2, ENSRNOT00000061047.5