Synj2bp synaptojanin 2 binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Synj2bpprovided by RGD
Official Full Name: synaptojanin 2 binding proteinprovided by RGD
Primary source: RGD:69400
See related: EnsemblRapid:ENSRNOG00000006399 AllianceGenome:RGD:69400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Omp25
Summary: Predicted to enable type II activin receptor binding activity. Involved in intracellular distribution of mitochondria. Located in mitochondrial outer membrane. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 228.4), Heart (RPKM 196.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (106920970..106958653, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (101189714..101227400, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (105224166..105261549, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142239 (e-PCR)
- UniSTS:231487

RH129534 (e-PCR)
- UniSTS:212836

RH128763 (e-PCR)
- UniSTS:212071

RH129934 (e-PCR)
- UniSTS:213222

D6Wox35 (e-PCR)
- UniSTS:518905

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type II activin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular distribution of mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
involved_in regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of endocytosis	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptojanin-2-binding protein

Names: NPW16; mitochondrial outer membrane protein 25; outer membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022599.2 → NP_072121.2 synaptojanin-2-binding protein

See identical proteins and their annotated locations for NP_072121.2

Status: VALIDATED

Source sequence(s)

AF260258, JAXUCZ010000006

UniProtKB/Swiss-Prot

A0JN00, Q9WVJ4

UniProtKB/TrEMBL

A0A8I6AL95, A6JDM8

Related

ENSRNOP00000009119.5, ENSRNOT00000009122.8

Conserved Domains (1) summary

cd00992
Location:13 → 97

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...