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    Cyp26c1 cytochrome P450, family 26, subfamily c, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 546726, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp26c1provided by MGI
    Official Full Name
    cytochrome P450, family 26, subfamily c, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:2679699
    See related
    Ensembl:ENSMUSG00000062432 AllianceGenome:MGI:2679699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG546726
    Summary
    Predicted to enable retinoic acid 4-hydroxylase activity and retinoic acid binding activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; neural crest cell development; and organelle fusion. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; branchial arch; epibranchial placode; future hindbrain; and inner ear. Orthologous to human CYP26C1 (cytochrome P450 family 26 subfamily C member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Cyp26c1 in Genome Data Viewer
    Location:
    19 C2; 19 32.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37673560..37681774)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37685112..37693320)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32294 Neighboring gene exocyst complex component 6 Neighboring gene predicted gene, 41842 Neighboring gene STARR-seq mESC enhancer starr_46060 Neighboring gene STARR-seq mESC enhancer starr_46061 Neighboring gene STARR-seq mESC enhancer starr_46062 Neighboring gene predicted gene, 32342 Neighboring gene cytochrome P450, family 26, subfamily a, polypeptide 1 Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development. Tahayato A, et al. Gene Expr Patterns, 2003 Aug. PMID 12915310
    2. Fluconazole alters CYP26 gene expression in mouse embryos. Tiboni GM, et al. Reprod Toxicol, 2009 Apr. PMID 19429397
    3. Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Roberts C, et al. Hum Mol Genet, 2006 Dec 1. PMID 17047027
    4. A paradoxical teratogenic mechanism for retinoic acid. Lee LM, et al. Proc Natl Acad Sci U S A, 2012 Aug 21. PMID 22869719, Free PMC Article
    5. Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development. El Shahawy M, et al. Int J Mol Sci, 2019 May 8. PMID 31072004, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium
      Title: Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.
    2. Fluconazole exposure did not alter CYP26a1 expression in mouse embryos.
      Title: Fluconazole alters CYP26 gene expression in mouse embryos.
    3. Raldh2 and Cyp26 generate shifting boundaries of retionic acid activity, controlling hindbrain segmental gene expression.
      Title: Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression.
    4. Cyp26c1 degrades retinoic acid within the equatorial retina during later eye development.
      Title: CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development.
    5. Activity of CYP26A1 and CYP26C1 is required for correct A-P patterning and production of migratory cranial neural crest cells in the developing mammalian brain.
      Title: CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinoic acid 4-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid 4-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within organelle fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retinoic acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinoic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinoic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 26C1
    NP_001098671.1
    XP_017173748.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105201.1 → NP_001098671.1  cytochrome P450 26C1

      See identical proteins and their annotated locations for NP_001098671.1

      Status: VALIDATED

      Source sequence(s)
      AC110212
      Consensus CDS
      CCDS50428.1
      UniProtKB/Swiss-Prot
      B2RXA7
      Related
      ENSMUSP00000073105.5, ENSMUST00000073391.5
      Conserved Domains (1) summary
      cl12078
      Location:40 → 500
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      37673560..37681774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318259.3 → XP_017173748.1  cytochrome P450 26C1 isoform X1

      UniProtKB/Swiss-Prot
      B2RXA7
      Conserved Domains (1) summary
      cl12078
      Location:40 → 500
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXA7.1 GenPept UniProtKB/Swiss-Prot:B2RXA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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