Eci2 enoyl-Coenzyme A delta isomerase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eci2provided by MGI
Official Full Name: enoyl-Coenzyme A delta isomerase 2provided by MGI
Primary source: MGI:MGI:1346064
See related: Ensembl:ENSMUSG00000021417 AllianceGenome:MGI:1346064
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drs1; Peci; Acbd2; Hca88
Summary: Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 30.7), liver adult (RPKM 24.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 14.23 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (35161731..35211098, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (34977748..35027115, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Eci2 (e-PCR), detects polymorphism
- UniSTS:545930

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	ISO Inferred from Sequence Orthology more info
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables intramolecular oxidoreductase activity, transposing C=C bonds	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: enoyl-CoA delta isomerase 2

Names: D3,D2-enoyl-CoA isomerase; delta(3),delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; enoyl-CoA delta isomerase 2, mitochondrial; peroxisomal 3,2-trans-enoyl-CoA isomerase; peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase

NP_001103801.1

EC 5.3.3.8

NP_035998.2

EC 5.3.3.8

XP_006516736.1

EC 5.3.3.8

XP_006516737.1

EC 5.3.3.8

XP_006516738.1

EC 5.3.3.8

XP_006516739.1

EC 5.3.3.8

XP_006516740.1

EC 5.3.3.8

XP_030103124.1

EC 5.3.3.8

XP_030103125.1

EC 5.3.3.8

XP_030103126.1

EC 5.3.3.8

XP_036013943.1

EC 5.3.3.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110331.1 → NP_001103801.1 enoyl-CoA delta isomerase 2 isoform a

See identical proteins and their annotated locations for NP_001103801.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AK009478, BQ176032, BY037058

Consensus CDS

CCDS49234.1

UniProtKB/Swiss-Prot

Q99M61, Q9D785, Q9WUR2

UniProtKB/TrEMBL

Q3TCD4

Related

ENSMUSP00000131735.2, ENSMUST00000171229.8

Conserved Domains (2) summary

pfam00887
Location:38 → 113

ACBP; Acyl CoA binding protein

cl23717
Location:139 → 389

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_011868.3 → NP_035998.2 enoyl-CoA delta isomerase 2 isoform b

See identical proteins and their annotated locations for NP_035998.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream initiation codon, compared to variant 1. The resulting protein (isoform b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AK009478, BQ176032, BY037058, CX242291

Consensus CDS

CCDS26450.1

UniProtKB/TrEMBL

Q3TCD4

Related

ENSMUSP00000021854.7, ENSMUST00000021854.14

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RNA

NR_073427.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' exon structure compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK009478, BQ176032, BY037058, BY238570

Related

ENSMUST00000110251.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

35161731..35211098 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516677.2 → XP_006516740.1 enoyl-CoA delta isomerase 2 isoform X1

See identical proteins and their annotated locations for XP_006516740.1

UniProtKB/TrEMBL

Q3TCD4

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006516676.4 → XP_006516739.1 enoyl-CoA delta isomerase 2 isoform X1

See identical proteins and their annotated locations for XP_006516739.1

UniProtKB/TrEMBL

Q3TCD4

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_030247264.1 → XP_030103124.1 enoyl-CoA delta isomerase 2 isoform X1

UniProtKB/TrEMBL

Q3TCD4

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006516674.4 → XP_006516737.1 enoyl-CoA delta isomerase 2 isoform X1

See identical proteins and their annotated locations for XP_006516737.1

UniProtKB/TrEMBL

Q3TCD4

Related

ENSMUSP00000137411.2, ENSMUST00000178421.8

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006516675.3 → XP_006516738.1 enoyl-CoA delta isomerase 2 isoform X1

See identical proteins and their annotated locations for XP_006516738.1

UniProtKB/TrEMBL

Q3TCD4

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_030247265.2 → XP_030103125.1 enoyl-CoA delta isomerase 2 isoform X2

Conserved Domains (1) summary

cl23717
Location:1 → 224

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006516673.4 → XP_006516736.1 enoyl-CoA delta isomerase 2 isoform X1

See identical proteins and their annotated locations for XP_006516736.1

UniProtKB/TrEMBL

Q3TCD4

Conserved Domains (2) summary

pfam00887
Location:5 → 80

ACBP; Acyl CoA binding protein

cl23717
Location:106 → 356

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_036158050.1 → XP_036013943.1 enoyl-CoA delta isomerase 2 isoform X2

Conserved Domains (1) summary

cl23717
Location:1 → 224

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_030247266.2 → XP_030103126.1 enoyl-CoA delta isomerase 2 isoform X2

Conserved Domains (1) summary

cl23717
Location:1 → 224

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001110332.1: Suppressed sequence

Description

NM_001110332.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.