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    cpf-2 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpf-2
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00000774
    Locus tag
    CELE_F56A8.6
    See related
    AllianceGenome:WB:WBGene00000774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing. Located in nuclear speck. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2) and CSTF2T (cleavage stimulation factor subunit 2 tau variant). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpf-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (13266932..13268883, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat domain, L domain-like;Transmembrane protein Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Syntaxin-1A homolog Neighboring gene Histone-lysine N-methyltransferase set-25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans. Cassart C, et al. Sci Adv, 2020 Dec. PMID 33298437, Free PMC Article
    2. The C. elegans 3' UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3'-UTR biology, and miRNA targeting. Steber HS, et al. Genome Res, 2019 Dec. PMID 31744903, Free PMC Article
    3. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
    4. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    5. Regulation of the hypertonic stress response by the 3' mRNA cleavage and polyadenylation complex. Urso SJ, et al. Genetics, 2023 May 4. PMID 36972377, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_499734.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13266932..13268883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067333.5 → NP_499734.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45577
      Conserved Domains (3) summary
      cd12398
      Location:20 → 94
      RRM_CSTF2_RNA15_like; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), yeast ortholog mRNA 3'-end-processing protein RNA15 and similar proteins
      pfam14304
      Location:299 → 334
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:115 → 194
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    Nucleotide Protein
    Heading Accession and Version

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