U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    num-1 Numb-related protein 1;PID domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180367, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    num-1
    Official Full Name
    Numb-related protein 1;PID domain-containing protein
    Primary source
    WormBase:WBGene00003830
    Locus tag
    CELE_T03D8.1
    See related
    AllianceGenome:WB:WBGene00003830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity and protein domain specific binding activity. Involved in endocytic recycling; phospholipid transport; and protein targeting to membrane. Located in basolateral plasma membrane and cytoplasm. Is expressed in several structures, including alimentary muscle; hermaphrodite gonad; nerve ring; pseudocoelom; and rectal valve cell. Orthologous to human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See num-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (20829811..20837619)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Gamma-glutamyltransferase;Gamma-glutamyltranspeptidase 1 Neighboring gene Receptor-type guanylate cyclase gcy-22 Neighboring gene Ground-like domain-containing protein Neighboring gene Neuroendocrine protein 7B2 Neighboring gene Small ribosomal subunit protein uS12m Neighboring gene Ribosomal RNA-processing protein 42 Neighboring gene Sugar phosphate phosphatase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans num-1 negatively regulates endocytic recycling. Nilsson L, et al. Genetics, 2008 May. PMID 18493060, Free PMC Article
    2. Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134025
    3. A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134024
    4. Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase. Nilsson L, et al. Traffic, 2011 Dec. PMID 21917090
    5. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. Poteryaev D, et al. EMBO J, 2007 Jan 24. PMID 17203072, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAT-1 is differentially spliced during development and that TAT-1C-specific splicing occurs in the intestine where NUM-1A is known to function.
      Title: Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Numb-related protein 1;PID domain-containing protein
    NP_001024097.1
    • Partially confirmed by transcript evidence
    NP_001024098.1
    • Confirmed by transcript evidence
    NP_001129904.1
    • Confirmed by transcript evidence
    NP_001256958.1
    • Confirmed by transcript evidence
    NP_508021.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20829811..20837619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136432.6 → NP_001129904.1  PID domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5BM46
      Conserved Domains (2) summary
      cd01268
      Location:181 → 316
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:410 → 445
      NumbF; NUMB domain

    2. NM_075620.6 → NP_508021.1  Numb-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BKB5, Q9XTY4, Q9XTY6
      Conserved Domains (2) summary
      cd01268
      Location:92 → 227
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:321 → 379
      NumbF; NUMB domain

    3. NM_001028927.3 → NP_001024098.1  Numb-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024098.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTY6
      Conserved Domains (2) summary
      cd01268
      Location:48 → 183
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:277 → 339
      NumbF; NUMB domain

    4. NM_001028926.5 → NP_001024097.1  Numb-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTY6

    5. NM_001270029.3 → NP_001256958.1  PID domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F1LIN5
      Conserved Domains (2) summary
      cd01268
      Location:34 → 169
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:263 → 298
      NumbF; NUMB domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTY6.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools