let-653 Protein let-653 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-653
Official Full Name: Protein let-653
Primary source: WormBase:WBGene00002827
Locus tag: CELE_C29E6.1
See related: AllianceGenome:WB:WBGene00002827
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: A structural constituent of cuticle. Involved in several processes, including embryonic ectodermal digestive tract morphogenesis; negative regulation of tube lumen cavitation; and positive regulation of vulval development. Located in apical plasma membrane; extracellular space; and supramolecular fiber. Is expressed in several structures, including excretory system; hypodermis; nervous system; rectal epithelial cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-653 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (11885613..11891082)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A C. elegans Zona Pellucida domain protein functions via its ZPc domain.
Title: A C. elegans Zona Pellucida domain protein functions via its ZPc domain.
hese data support a model in which the PAN domains regulate the ability of the LET-653 ZP domain to interact with other factors at the apical membrane, and this ZP domain interaction promotes expansion and maintenance of lumen diameter.
Title: Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C29E6.1 (e-PCR)
- UniSTS:313769

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of cuticle	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic ectodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tube lumen cavitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in supramolecular fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein let-653

NP_001021336.2

Confirmed by transcript evidence

NP_001021337.1

Confirmed by transcript evidence

NP_001255594.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11885613..11891082

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026166.5 → NP_001021337.1 Protein let-653 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27394

Conserved Domains (1) summary

cd01099
Location:124 → 208

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
NM_001026165.7 → NP_001021336.2 Protein let-653 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021336.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECH8, Q27394, Q5WRN8

Conserved Domains (2) summary

smart00241
Location:606 → 727

ZP; Zona pellucida (ZP) domain

cd01099
Location:124 → 208

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
NM_001268665.4 → NP_001255594.1 Protein let-653 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27394

Conserved Domains (2) summary

smart00241
Location:487 → 608

ZP; Zona pellucida (ZP) domain

cd01099
Location:124 → 208

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...