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    lev-1 Acetylcholine receptor subunit beta-type lev-1 [ Caenorhabditis elegans ]

    Gene ID: 178269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lev-1
    Official Full Name
    Acetylcholine receptor subunit beta-type lev-1
    Primary source
    WormBase:WBGene00002974
    Locus tag
    CELE_F09E8.7
    See related
    AllianceGenome:WB:WBGene00002974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including inorganic cation transmembrane transport; monoatomic ion transmembrane transport; and regulation of egg-laying behavior. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Is expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; cocaine abuse; congenital myasthenic syndrome (multiple); and lung cancer (multiple). Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lev-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (13174157..13179395, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-14 Neighboring gene Armadillo repeat-containing protein 5 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Echolocation: a PCR-based strategy for reliably and rapidly mapping transposon insertion sites. Barnes TM. Nucleic Acids Res, 1990 Nov 25. PMID 2174549, Free PMC Article
    2. The levamisole receptor, a cholinergic receptor of the nematode Caenorhabditis elegans. Lewis JA, et al. Mol Pharmacol, 1987 Feb. PMID 3807894
    3. Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans. Izquierdo PG, et al. J Biol Chem, 2022 Jan. PMID 34864060, Free PMC Article
    4. Recovery of duplications by drug resistance selection in Caenorhabditis elegans. Marra MA, et al. Genome, 1994 Aug. PMID 7958827
    5. Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. Fleming JT, et al. J Neurosci, 1997 Aug 1. PMID 9221782, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetylcholine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acetylcholine receptor subunit beta-type lev-1
    NP_001255704.1
    • Confirmed by transcript evidence
    NP_001255705.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13174157..13179395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268776.3 → NP_001255705.1  Acetylcholine receptor subunit beta-type lev-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02278, Q19273, Q27218
      Conserved Domains (3) summary
      TIGR00860
      Location:15 → 474
      LIC; Cation transporter family protein
      pfam02931
      Location:38 → 238
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:245 → 470
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001268775.4 → NP_001255704.1  Acetylcholine receptor subunit beta-type lev-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRN0
      Conserved Domains (3) summary
      TIGR00860
      Location:15 → 449
      LIC; Cation transporter family protein
      pfam02931
      Location:38 → 238
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:245 → 445
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27218.1

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