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    T28B8.4 Proteasome activator complex subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 13181077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T28B8.4
    Official Full Name
    Proteasome activator complex subunit 4
    Primary source
    WormBase:WBGene00012115
    Locus tag
    CELE_T28B8.4
    See related
    AllianceGenome:WB:WBGene00012115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T28B8.4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    23
    Sequence:
    Chromosome: I; NC_003279.8 (8160468..8168711)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Calmodulin-binding domain-containing protein Neighboring gene Serpentine Receptor, class Z

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Proteasome activator complex subunit 4
    NP_001263461.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8160468..8168711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276532.4 → NP_001263461.1  Proteasome activator complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K7ZUR1
      Conserved Domains (2) summary
      pfam11919
      Location:1789 → 1873
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:334 → 860
      BLM10_mid; Proteasome-substrate-size regulator, mid region
    Nucleotide Protein
    Heading Accession and Version

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