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    cni-1 Protein cornichon homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 179801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cni-1
    Official Full Name
    Protein cornichon homolog 1
    Primary source
    WormBase:WBGene00011648
    Locus tag
    CELE_T09E8.3
    See related
    AllianceGenome:WB:WBGene00011648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including negative regulation of anterograde synaptic vesicle transport; negative regulation of receptor localization to synapse; and regulation of neurotransmitter receptor activity. Located in several cellular components, including Golgi apparatus; neuronal cell body; and perinuclear endoplasmic reticulum. Is expressed in nervous system. Orthologous to several human genes including CNIH2 (cornichon family AMPA receptor auxiliary protein 2) and CNIH1 (cornichon family member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cni-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (13180330..13181534)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Non-centrosomal microtubule array protein 1 Neighboring gene ncRNA Neighboring gene High Incidence of Males (increased X chromosome loss) Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Serpentine Receptor, class T

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Brockie PJ, et al. Neuron, 2013 Oct 2. PMID 24094107, Free PMC Article
    2. RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway. Zhang D, et al. J Cell Biol, 2012 Jan 9. PMID 22213799, Free PMC Article
    3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of NMDA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein cornichon homolog 1
    NP_506278.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13180330..13181534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073877.7 → NP_506278.1  Protein cornichon homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506278.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22361
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 135
      Cornichon; Cornichon protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22361.2

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