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    vit-6 Vitellogenin-6 [ Caenorhabditis elegans ]

    Gene ID: 177619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vit-6
    Official Full Name
    Vitellogenin-6
    Primary source
    WormBase:WBGene00006930
    Locus tag
    CELE_K07H8.6
    See related
    AllianceGenome:WB:WBGene00006930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid transporter activity. Involved in negative regulation of protein oxidation; negative regulation of reactive oxygen species biosynthetic process; and positive regulation of cholesterol import. Predicted to be located in extracellular region. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vit-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (8261157..8266459)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Lipoprotein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two distinct yolk lipoprotein complexes from Caenorhabditis elegans. Sharrock WJ, et al. J Biol Chem, 1990 Aug 25. PMID 2387862
    2. Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression. Fischer M, et al. Mol Nutr Food Res, 2012 Jun. PMID 22707270
    3. SL1 trans-splicing specified by AU-rich synthetic RNA inserted at the 5' end of Caenorhabditis elegans pre-mRNA. Conrad R, et al. RNA, 1995 Apr. PMID 7585246, Free PMC Article
    4. Dynamic changes of the Caenorhabditis elegans proteome during ontogenesis assessed by quantitative analysis with 15N metabolic labeling. Geillinger KE, et al. J Proteome Res, 2012 Sep 7. PMID 22900790
    5. Regulated expression of a vitellogenin fusion gene in transgenic nematodes. Spieth J, et al. Dev Biol, 1988 Nov. PMID 3181632

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that induction of vit-6 (in response to the phytoestrogen daidzein) increases resistance of C. elegans to pathogenic bacteria (Photorhabdus luminescens here) and heat shock/stress.
      Title: Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nutrient reservoir activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vitellogenin-6
    NP_001023274.1
    • Confirmed by transcript evidence
    NP_001023276.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8261157..8266459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028103.4 → NP_001023274.1  Vitellogenin-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18948
      Conserved Domains (3) summary
      smart00216
      Location:1339 → 1495
      VWD; von Willebrand factor (vWF) type D domain
      pfam01347
      Location:34 → 646
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam09172
      Location:679 → 979
      DUF1943; Domain of unknown function (DUF1943)

    2. NM_001028105.7 → NP_001023276.1  Vitellogenin-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45176, P18948, Q7KPP7, Q7YXH2
      Conserved Domains (3) summary
      smart00216
      Location:1339 → 1495
      VWD; von Willebrand factor (vWF) type D domain
      pfam01347
      Location:34 → 646
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam09172
      Location:679 → 979
      DUF1943; Domain of unknown function (DUF1943)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18948.5

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