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    clec-41 Cubilin [ Caenorhabditis elegans ]

    Gene ID: 179797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clec-41
    Official Full Name
    Cubilin
    Primary source
    WormBase:WBGene00007153
    Locus tag
    CELE_B0365.6
    See related
    AllianceGenome:WB:WBGene00007153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of chemotaxis. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clec-41 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (13134903..13138101, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 4 domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Dynein Heavy Chain Neighboring gene Non-centrosomal microtubule array protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis. O'Brien D, et al. Cell Rep, 2018 Jun 26. PMID 29949773, Free PMC Article
    2. The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis. Deffit SN, et al. Elife, 2017 Sep 19. PMID 28925356, Free PMC Article
    3. Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins. Pees B, et al. PLoS Pathog, 2021 Apr. PMID 33793670, Free PMC Article
    4. Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing. Ganem NS, et al. Cell Rep, 2019 Apr 23. PMID 31018137, Free PMC Article
    5. Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans. Schulenburg H, et al. Immunobiology, 2008. PMID 18406370

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in positive regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cubilin
    NP_506271.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13134903..13138101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073870.5 → NP_506271.1  Cubilin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90732
      Conserved Domains (3) summary
      smart00034
      Location:163 → 281
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00042
      Location:444 → 542
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      cd00041
      Location:301 → 393
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version

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