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    glr-4 GLutamate Receptor family (AMPA) [ Caenorhabditis elegans ]

    Gene ID: 174258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glr-4
    Official Full Name
    GLutamate Receptor family (AMPA)
    Primary source
    WormBase:WBGene00001615
    Locus tag
    CELE_C06A8.9
    See related
    AllianceGenome:WB:WBGene00001615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in DVA; body ganglion; cholinergic neurons; and head neurons. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glr-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    21
    Sequence:
    Chromosome: II; NC_003280.10 (7785100..7794322, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Spindly-like protein spdl-1 Neighboring gene Skp1-related protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation. Li Y, et al. Cell Rep, 2023 Mar 28. PMID 36897776, Free PMC Article
    2. UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans. Von Stetina SE, et al. Genes Dev, 2007 Feb 1. PMID 17289921, Free PMC Article
    3. Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans. Wang S, et al. Ecotoxicol Environ Saf, 2021 Jul 1. PMID 33892344
    4. Glutamate receptor channel signatures. Sprengel R, et al. Trends Pharmacol Sci, 2001 Jan. PMID 11165660
    5. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm N, et al. J Biol Chem, 2003 Nov 7. PMID 12930835

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GLutamate Receptor family (AMPA)
    NP_001254126.1
    • Product from WormBase gene class glr;
      Confirmed by transcript evidence
    NP_001359784.1
    • Product from WormBase gene class glr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7785100..7794322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373747.3 → NP_001359784.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KY73
      Conserved Domains (2) summary
      cl10011
      Location:30 → 383
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:410 → 775
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. NM_001267197.2 → NP_001254126.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17697
      Conserved Domains (4) summary
      cd06382
      Location:30 → 385
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      pfam00060
      Location:533 → 810
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:45 → 365
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:410 → 775
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version

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