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    wht-4 ABC transporter domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wht-4
    Official Full Name
    ABC transporter domain-containing protein
    Primary source
    WormBase:WBGene00017179
    Locus tag
    CELE_F02E11.1
    See related
    AllianceGenome:WB:WBGene00017179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG1 (ATP binding cassette subfamily G member 1); ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)); and ABCG4 (ATP binding cassette subfamily G member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wht-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (3278934..3281713)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ORF56 Neighboring gene Smr domain-containing protein Neighboring gene ncRNA Neighboring gene NEPrilysin metallopeptidase family Neighboring gene SCP domain-containing protein Neighboring gene Serpentine Receptor, class I Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
    2. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ABC transporter domain-containing protein
    NP_494495.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3278934..3281713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062094.4 → NP_494495.3  ABC transporter domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494495.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16574
      Conserved Domains (1) summary
      TIGR00955
      Location:49 → 636
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    Nucleotide Protein
    Heading Accession and Version

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