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    ztf-4 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ztf-4
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00020399
    Locus tag
    CELE_T10B11.3
    See related
    AllianceGenome:WB:WBGene00020399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Is expressed in several structures, including gonadal primordium; head; midbody; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including RALYL (RALY RNA binding protein like); RALY (RALY heterogeneous nuclear ribonucleoprotein); and HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ztf-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (6926257..6929665)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein 15 Neighboring gene Transmembrane protein Neighboring gene Ceramide kinase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
    2. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Xu L, et al. Nature, 2003 Sep 18. PMID 13679922
    3. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_491976.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6926257..6929665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059575.5 → NP_491976.2  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491976.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZI2
      Conserved Domains (2) summary
      COG0724
      Location:64 → 272
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:83 → 151
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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