cul-4 Cullin-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cul-4
Official Full Name: Cullin-4
Primary source: WormBase:WBGene00000839
Locus tag: CELE_F45E12.3
See related: AllianceGenome:WB:WBGene00000839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in embryonic cell; germ line; gonad; intestine; and oocyte. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to several human genes including CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cul-4 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (7302101..7305758)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our studies highlight previously unknown functions of CRL4 in C. elegans meiosis and show that CUL-4 likely plays multiple roles in meiosis that are essential for maintaining genome integrity.
Title: CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline.
Data show that SKN-1 protein levels, nuclear accumulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL-4/DDB-1 ubiquitin ligase to presumably target the transcription factor for proteasomal degradation.
Title: The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.
CUL-4 has a role in preventing rereplication by promoting the phosphorylation and subsequent translocation of CDC-6 from the nucleus during S phase.
Title: C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway.
Caenorhabditis elegans DDB-1 is required for the degradation of CDT-1 during S phase. DDB-1 interacts specifically with CUL-4 but not with other C. elegans cullins.
Title: The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.
proposal that CUL-4 prevents aberrant re-initiation of DNA replication, at least in part, by facilitating the degradation of CDT-1
Title: CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C30G12.1 (e-PCR)
- UniSTS:308671

F45E12.3 (e-PCR)
- UniSTS:311237

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cullin-4

NP_495525.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7302101..7305758

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063124.8 → NP_495525.2 Cullin-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495525.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17392, Q20428

Conserved Domains (4) summary

smart00182
Location:513 → 652

CULLIN; Cullin

pfam00888
Location:123 → 740

Cullin; Cullin family

pfam10557
Location:774 → 831

Cullin_Nedd8; Cullin protein neddylation domain

cl21453
Location:253 → 336

PKc_like; Protein Kinases, catalytic domain