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    ace-3 Carboxylic ester hydrolase [ Caenorhabditis elegans ]

    Gene ID: 175076, updated on 9-Dec-2024

    Summary

    Official Symbol
    ace-3
    Official Full Name
    Carboxylic ester hydrolase
    Primary source
    WormBase:WBGene00000037
    Locus tag
    CELE_Y48B6A.8
    See related
    AllianceGenome:WB:WBGene00000037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables acetylcholinesterase activity and protein homodimerization activity. Involved in several processes, including acetylcholine catabolic process; hatching; and regulation of backward locomotion. Predicted to be located in synaptic cleft. Predicted to be active in extracellular space and plasma membrane. Is expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); drug dependence (multiple); myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ace-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (14205635..14210214)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Carboxylic ester hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Homolog of Odr-2 (Two) Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetylcholinesterase activity  
    enables acetylcholinesterase activity PubMed 
    enables acetylcholinesterase activity  
    enables carboxylic ester hydrolase activity  
    enables cholinesterase activity  
    enables identical protein binding PubMed 
    enables protein homodimerization activity PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space  
    is_active_in plasma membrane  
    located_in synaptic cleft  

    General protein information

    Preferred Names
    Carboxylic ester hydrolase
    NP_496963.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14205635..14210214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064562.6NP_496963.1  Carboxylic ester hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61459, Q9U295
      Conserved Domains (2) summary
      COG0657
      Location:123234
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:28564
      COesterase; Carboxylesterase family
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