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    cif-1 COP9/Signalosome and eIF3 complex-shared subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 177236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cif-1
    Official Full Name
    COP9/Signalosome and eIF3 complex-shared subunit 1
    Primary source
    WormBase:WBGene00019543
    Locus tag
    CELE_K08F11.3
    See related
    AllianceGenome:WB:WBGene00019543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3M (eukaryotic translation initiation factor 3 subunit M). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cif-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (4706854..4710755, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate dehydrogenase, mitochondrial;Transketolase-like pyrimidine-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Tyrosine--tRNA ligase Neighboring gene Mitochondrial Rho GTPase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in Caenorhabditis elegans. Uozumi T, et al. Genes Cells, 2015 Oct. PMID 26223767
    2. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
    3. Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling. Hoffmann M, et al. Dev Biol, 2010 Mar 15. PMID 20004187
    4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KO8F11.3 is identified as a stoichiometric and functionally important subunit of the CSN complex; it regulates mel-26 levels in the Caenorhabditis elegans embryo.
      Title: CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COP9/Signalosome and eIF3 complex-shared subunit 1
    NP_500618.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4706854..4710755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068217.7 → NP_500618.1  COP9/Signalosome and eIF3 complex-shared subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500618.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94261
      Conserved Domains (1) summary
      pfam01399
      Location:245 → 347
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94261.1

    Gene LinkOut

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