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    lmp-2 Lysosome-associated membrane glycoprotein 5 [ Caenorhabditis elegans ]

    Gene ID: 180467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmp-2
    Official Full Name
    Lysosome-associated membrane glycoprotein 5
    Primary source
    WormBase:WBGene00015471
    Locus tag
    CELE_C05D9.2
    See related
    AllianceGenome:WB:WBGene00015471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in establishment of protein localization to organelle. Predicted to be located in membrane. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in intestine. Orthologous to human LAMP1 (lysosomal associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lmp-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (1125615..1128288)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain;WG repeat-containing protein Neighboring gene PX domain-containing protein Neighboring gene VWFA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of chaperone-mediated autophagy prevents glucotoxicity in the Caenorhabditis elegans mev-1 mutant by activation of the proteasome. Eisermann DJ, et al. Biochem Biophys Res Commun, 2017 Feb 26. PMID 28089866
    2. The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. Li Y, et al. J Cell Biol, 2016 Oct 24. PMID 27810910, Free PMC Article
    3. UNC-46 is required for trafficking of the vesicular GABA transporter. Schuske K, et al. Nat Neurosci, 2007 Jul. PMID 17558401
    4. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Florez-McClure ML, et al. Autophagy, 2007 Nov-Dec. PMID 17675890
    5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lysosome-associated membrane glycoprotein 5
    NP_001379622.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1125615..1128288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392725.1 → NP_001379622.1  Lysosome-associated membrane glycoprotein 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYK0
      Conserved Domains (1) summary
      pfam01299
      Location:29 → 214
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    Nucleotide Protein
    Heading Accession and Version

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